U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

VP35 polymerase complex protein [ Reston ebolavirus ]

Gene ID: 955189, updated on 18-Aug-2023

Summary

Go to the top of the page Help
Gene symbol
VP35
Gene description
polymerase complex protein
Locus tag
REBOVgp2
Gene type
protein coding
RNA name
VP35
RefSeq status
PROVISIONAL
Organism
Reston ebolavirus (isolate: Reston virus/M.fascicularis-tc/USA/1989/Philippines89-Pennsylvania)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Filoviridae; Ebolavirus
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_004161.1 (3019..4413)

NC_004161.1Genomic Context describing neighboring genes Neighboring gene nucleoprotein Neighboring gene matrix protein Neighboring gene second secreted glycoprotein;small secreted glycoprotein;spike glycoprotein Neighboring gene minor nucleoprotein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_004161.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structures of Ebola and Reston Virus VP35 Oligomerization Domains and Comparative Biophysical Characterization in All Ebolavirus Species. Zinzula L, et al. Structure, 2019 Jan 2. PMID 30482729
  2. Ebolavirus VP35 coats the backbone of double-stranded RNA for interferon antagonism. Bale S, et al. J Virol, 2013 Sep. PMID 23824825, Free PMC Article
  3. Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression. Kimberlin CR, et al. Proc Natl Acad Sci U S A, 2010 Jan 5. PMID 20018665, Free PMC Article
  4. VP40 octamers are essential for Ebola virus replication. Hoenen T, et al. J Virol, 2005 Feb. PMID 15650213, Free PMC Article
  5. Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence. Kash JC, et al. J Virol, 2006 Mar. PMID 16501110, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study demonstrates that the EBOV VP35 oligomerization domain is capable of assembling into homo-trimeric as well as homo-tetrameric complexes, whereas RESTV, SUDV, TAFV, and BDBV VP35 oligomerization domains exclusively associate into homo-tetramers.
    Title: Structures of Ebola and Reston Virus VP35 Oligomerization Domains and Comparative Biophysical Characterization in All Ebolavirus Species.
  2. Authors demonstrate that ebolavirus VP35 also coats the dsRNA backbone in solution, although binding to the dsRNA ends probably constitutes the initial binding event.
    Title: Ebolavirus VP35 coats the backbone of double-stranded RNA for interferon antagonism.
  3. Data present unbound and dsRNA-bound crystal structures of the dsRNA-binding domain of Reston ebolavirus VP35, which show that VP35 forms an unusual, asymmetric dimer on dsRNA binding.
    Title: Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

regulatory

  • Loc: 4403-4413 regulatory_class = polyA_signal_sequence

General protein information

Go to the top of the page Help
Preferred Names
polymerase complex protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004161.1 Reference assembly

    Range
    3019..4413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_690581.1 polymerase complex protein [Reston ebolavirus]

    See identical proteins and their annotated locations for NP_690581.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q8JPY0
    UniProtKB/TrEMBL
    A0A1I9VT53, L7RF08
    Conserved Domains (1) summary
    pfam02097
    Location:11 → 329
    Filo_VP35; Filoviridae VP35
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials