recA DNA recombination/repair protein RecA [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: recA
Official Full Name: DNA recombination/repair protein RecA
Primary source: ECOCYC:EG10823
Locus tag: b2699
See related: ASAP:ABE-0008876
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2694; lexB; recH; rnmB; srf; tif; umuB; zab
Summary: RecA does not bind to DNA with extensive stem-loop structures, except in the presence of SSB. [More information is available at EcoGene: EG10823]. In Escherichia coli, RecA serves a variety of biochemical functions: [More information is available at EcoCyc: EG10823].
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Genomic context

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Sequence:: NC_000913.3 (2822708..2823769, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RecA and SSB genome-wide distribution in ssDNA gaps and ends in Escherichia coli.
Title: RecA and SSB genome-wide distribution in ssDNA gaps and ends in Escherichia coli.
IS26-mediated loss of the translocatable unit from Tn4352B requires the presence of the recA1 allele.
Title: IS26-mediated loss of the translocatable unit from Tn4352B requires the presence of the recA1 allele.
Host cell RecA activates a mobile element-encoded mutagenic DNA polymerase.
Title: Host cell RecA activates a mobile element-encoded mutagenic DNA polymerase.
Redox controls RecA protein activity via reversible oxidation of its methionine residues.
Title: Redox controls RecA protein activity via reversible oxidation of its methionine residues.
An Epistasis Analysis of recA and recN in Escherichia coli K-12.
Title: An Epistasis Analysis of recA and recN in Escherichia coli K-12.
Mismatch sensing by nucleofilament deciphers mechanism of RecA-mediated homologous recombination.
Title: Mismatch sensing by nucleofilament deciphers mechanism of RecA-mediated homologous recombination.
Single-molecule live-cell imaging reveals RecB-dependent function of DNA polymerase IV in double strand break repair.
Title: Single-molecule live-cell imaging reveals RecB-dependent function of DNA polymerase IV in double strand break repair.
E. coli Rep helicase and RecA recombinase unwind G4 DNA and are important for resistance to G4-stabilizing ligands.
Title: E. coli Rep helicase and RecA recombinase unwind G4 DNA and are important for resistance to G4-stabilizing ligands.
Upon DNA damage, the storage structures dissolve and the cytosolic pool of RecA rapidly nucleates to form early SOS-signaling complexes, maturing into DNA-bound RecA bundles at later time points. Both before and after SOS induction, RecA* largely appears at locations distal from replisomes. Upon completion of repair, RecA storage structures reform.
Title: Spatial and temporal organization of RecA in the Escherichia coli DNA-damage response.
These results suggest that fatal genomic rearrangements due to the recombination of small regions of accidental homology may be reduced if RecA-mediated strand exchange is immediately followed by DNA synthesis by a slow polymerase.
Title: Slow extension of the invading DNA strand in a D-loop formed by RecA-mediated homologous recombination may enhance recognition of DNA homology.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent activity, acting on DNA	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEP Inferred from Expression Pattern more info	PubMed
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in SOS response	IDA Inferred from Direct Assay more info	PubMed
involved_in SOS response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within SOS response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SOS response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SOS response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homologous recombination	TAS Traceable Author Statement more info	PubMed
involved_in recombinational repair	TAS Traceable Author Statement more info	PubMed
involved_in response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translesion synthesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of DNA polymerase V complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IC Inferred by Curator more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA recombination/repair protein RecA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

2822708..2823769 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_417179.1 DNA recombination/repair protein RecA [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_417179.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A485JBB4

Conserved Domains (1) summary

PRK09354
Location:1 → 348

recA; recombinase A; Provisional