U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

yajO 1-deoxyxylulose-5-phosphate synthase YajO [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946903, updated on 19-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
yajO
Official Full Name
1-deoxyxylulose-5-phosphate synthase YajO
Primary source
ECOCYC:G6236
Locus tag
b0419
See related
ASAP:ABE-0001457
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0413
Summary
YajO converts 2-carboxybenzaldehyde, like other AKR7A family enzymes, however specificities toward other substrates was not demonstrated. [More information is available at EcoGene: EG13611]. Overexpression of YajO from a multicopy plasmid leads to resistance to the HMP (4-amino-2-methyl-5-hydroxymethylpyrimidine) analog bacimethrin. [More information is available at EcoCyc: G6236].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (437161..438135, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene transcription antitermination protein NusB Neighboring gene thiamine monophosphate kinase Neighboring gene phosphatidylglycerophosphatase A Neighboring gene 1-deoxy-D-xylulose-5-phosphate synthase Neighboring gene geranyl diphosphate/farnesyl diphosphate synthase Neighboring gene exodeoxyribonuclease VII subunit XseB

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Isolation and preliminary characterization of Escherichia coli mutants deficient in exonuclease VII. Vales LD, et al. J Bacteriol, 1983 Sep. PMID 6350262, Free PMC Article
  2. Cloning and nucleotide sequence of the ispA gene responsible for farnesyl diphosphate synthase activity in Escherichia coli. Fujisaki S, et al. J Biochem, 1990 Dec. PMID 2089044
  3. Conversion of methylglyoxal to acetol by Escherichia coli aldo-keto reductases. Ko J, et al. J Bacteriol, 2005 Aug. PMID 16077126, Free PMC Article
  4. Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli. Kerner MJ, et al. Cell, 2005 Jul 29. PMID 16051146
  5. A genetic screen for the identification of thiamin metabolic genes. Lawhorn BG, et al. J Biol Chem, 2004 Oct 15. PMID 15292217

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within isoprenoid biosynthetic process via mevalonate EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within thiamine metabolic process EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
1-deoxyxylulose-5-phosphate synthase YajO

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    437161..438135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414953.2 1-deoxyxylulose-5-phosphate synthase YajO [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414953.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9WYK3, A0AAE9Q7H0
    Conserved Domains (1) summary
    cd19079
    Location:2 → 312
    AKR_EcYajO-like; Escherichia coli YajO and similar proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.