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pntA pyridine nucleotide transhydrogenase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946628, updated on 2-May-2024

Summary

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Gene symbol
pntA
Gene description
pyridine nucleotide transhydrogenase subunit alpha
Primary source
ASAP:ABE-0005354
Locus tag
b1603
See related
ECOCYC:EG10744
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1598
Summary
[More information is available at EcoGene: EG10744]. Pyridine nucleotide transhydrogenase catalyzes the reversible transfer of a hydride ion equivalent between NAD and NADP. [More information is available at EcoCyc: EG10744].
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Genomic context

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Sequence:
NC_000913.3 (1676371..1677903, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene autoinducer 2 exporter Neighboring gene pyridine nucleotide transhydrogenase subunit beta Neighboring gene DUF1471 domain-containing protein YdgH Neighboring gene putative arginine:ornithine antiporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Energization of energy-dependent transhydrogenase of Escherichia coli at a second site of energy conservation. Bragg PD, et al. Arch Biochem Biophys, 1974 Aug. PMID 4153348
  2. Inhibition of proton-transfer steps in transhydrogenase by transition metal ions. Whitehead SJ, et al. Biochim Biophys Acta, 2009 Oct. PMID 19505432
  3. Proton-translocating transhydrogenase: an update of unsolved and controversial issues. Pedersen A, et al. J Bioenerg Biomembr, 2008 Oct. PMID 18972197
  4. Purification of recombinant membrane proteins tagged with calmodulin-binding domains by affinity chromatography on calmodulin-agarose: example of nicotinamide nucleotide transhydrogenase. Pestov NB, et al. Nat Protoc, 2007. PMID 17401354
  5. Molecular recognition between protein and nicotinamide dinucleotide in intact, proton-translocating transhydrogenase studied by ATR-FTIR Spectroscopy. Iwaki M, et al. J Am Chem Soc, 2006 Mar 1. PMID 16492047

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct transcription factors regulated the PntA, PntB and UdhA promoters.
    Title: Distinct transcriptional regulation of the two Escherichia coli transhydrogenases PntAB and UdhA.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Nucleotide sequence of the pntA and pntB genes encoding the pyridine nucleotide transhydrogenase of Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD(P)+ transhydrogenase (AB-specific) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD(P)+ transhydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD(P)+ transhydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD(P)+ transhydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in NADPH regeneration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NADPH regeneration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NADPH regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton export across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
pyridine nucleotide transhydrogenase subunit alpha
NP_416120.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1676371..1677903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416120.1 pyridine nucleotide transhydrogenase subunit alpha [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416120.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8QRY8, A0A8S7FGR8
    Conserved Domains (1) summary
    PRK09424
    Location:1 → 509
    pntA; Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha
Nucleotide Protein
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