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uup ATP-binding protein Uup [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945566, updated on 27-Nov-2023

Summary

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Gene symbol
uup
Gene description
ATP-binding protein Uup
Primary source
ASAP:ABE-0003213
Locus tag
b0949
See related
ECOCYC:G6489
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0940; ycbH; ycbI
Summary
Has two ABC ATPase domains; ATPase activity is essential for function. [More information is available at EcoGene: EG13134]. Uup is a cytosolic ATP-binding cassette (ABC) protein . [More information is available at EcoCyc: G6489].
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Genomic context

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Sequence:
NC_000913.3 (1009964..1011871)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell division protein ZapC Neighboring gene 6-N-hydroxylaminopurine resistance protein Neighboring gene fused 23S rRNA m(2)G2445 methyltransferase and 23S rRNA m(7)G2069 methyltransferase Neighboring gene intermembrane transport protein PqiA Neighboring gene intermembrane transport protein PqiB Neighboring gene intermembrane transport lipoprotein PqiC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C-terminal domain of the Uup ATP-binding cassette ATPase is an essential folding domain that binds to DNA. Burgos Zepeda MY, et al. Biochim Biophys Acta, 2010 Apr. PMID 19948254
  2. Deletion of the Escherichia coli uup gene encoding a protein of the ATP binding cassette superfamily affects bacterial competitiveness. Murat D, et al. Res Microbiol, 2008 Nov-Dec. PMID 18848624
  3. ATP hydrolysis is essential for the function of the Uup ATP-binding cassette ATPase in precise excision of transposons. Murat D, et al. J Biol Chem, 2006 Mar 10. PMID 16407313
  4. Sequence analysis of twin ATP binding cassette proteins involved in translational control, antibiotic resistance, and ribonuclease L inhibition. Kerr ID. Biochem Biophys Res Commun, 2004 Feb 27. PMID 15013441
  5. Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins. Romero ZJ, et al. Nucleic Acids Res, 2020 Jan 10. PMID 31665437, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD.
    Title: Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD.
  2. RadD protein suppresses crossovers, and Uup prevents nucleoid mis-segregation during Dna replication of defective DNA sequences.
    Title: Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins.
  3. compared the DNA binding activities of three versions of the protein (Uup, UupDeltaCTD and CTD) by an electrophoretic mobility shift assay. CTD is able to bind DNA although less efficiently than intact Uup and UupDeltaCTD (C-terminal domain).
    Title: C-terminal domain of the Uup ATP-binding cassette ATPase is an essential folding domain that binds to DNA.
  4. Deletion of the uup gene, which encodes a soluble ATP binding cassette (ABC) ATPase, renders the mutant strain sensitive to its parent when they are grown together in the same medium.
    Title: Deletion of the Escherichia coli uup gene encoding a protein of the ATP binding cassette superfamily affects bacterial competitiveness.
  5. ATP hydrolysis at the two ATP-binding cassette domains is strictly coordinated and is essential for the cytosolic ATP-binding cassette (ABC) ATPase function of Uup in vivo.
    Title: ATP hydrolysis is essential for the function of the Uup ATP-binding cassette ATPase in precise excision of transposons.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within postreplication repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ATP-binding protein Uup

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1009964..1011871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415469.1 ATP-binding protein Uup [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415469.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7JS95
    Conserved Domains (1) summary
    PRK11147
    Location:1 → 635
    PRK11147; ABC transporter ATPase component; Reviewed
Nucleotide Protein
Heading Accession and Version

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