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tagA N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 936810, updated on 12-Feb-2021

Summary

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Gene symbol
tagA
Gene description
N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase
Locus tag
BSU_35750
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU35750
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Genomic context

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Sequence:
NC_000964.3 (3681370..3682140)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase) Neighboring gene UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase Neighboring gene glycerol-3-phosphate cytidylyltransferase Neighboring gene teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase Neighboring gene putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The N-acetylmannosamine transferase catalyzes the first committed step of teichoic acid assembly in Bacillus subtilis and Staphylococcus aureus. D'Elia MA, et al. J Bacteriol, 2009 Jun. PMID 19376878, Free PMC Article
  2. Acceptor substrate selectivity and kinetic mechanism of Bacillus subtilis TagA. Zhang YH, et al. Biochemistry, 2006 Sep 12. PMID 16953575, Free PMC Article
  3. Localization and interactions of teichoic acid synthetic enzymes in Bacillus subtilis. Formstone A, et al. J Bacteriol, 2008 Mar. PMID 18156271, Free PMC Article
  4. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  5. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TagA encodes the first committed step in wall teichoic acid synthesis and is dispensable for growth in vitro.
    Title: The N-acetylmannosamine transferase catalyzes the first committed step of teichoic acid assembly in Bacillus subtilis and Staphylococcus aureus.
  2. Data show that there is a complex network of interactions involving TagA and the cell shape determinants MreC and MreD and TagA is part of a large multienzyme complex mediating the synthesis and export of WTA precursors.
    Title: Localization and interactions of teichoic acid synthetic enzymes in Bacillus subtilis.
  3. TagA is a metal ion-independent glycosyltransferase that follows a steady-state ordered mechanism in which UDP-ManNAc binds first and UDP is released last.
    Title: Acceptor substrate selectivity and kinetic mechanism of Bacillus subtilis TagA.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase
NP_391456.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_391456.1 N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_391456.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P27620
    Conserved Domains (1) summary
    TIGR00696
    Location:55 → 230
    wecG_tagA_cpsF; bacterial polymer biosynthesis proteins, WecB/TagA/CpsF family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27620.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials