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tor FRAP subfamily protein kinase [ Dictyostelium discoideum AX4 ]

Gene ID: 8623240, updated on 11-Apr-2024

Summary

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Gene symbol
tor
Gene description
FRAP subfamily protein kinase
Primary source
dictyBase:DDB_G0281569
Locus tag
DDB_G0281569
Gene type
protein coding
RNA name
protein kinase, Atypical group
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium
Old locus tag
DDBDRAFT_0204659; DDBDRAFT_0214908; DDB_0204659; DDB_0214908
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Genomic context

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Location:
chromosome: 3
Exon count:
3
Sequence:
Chromosome: 3; NC_007089.4 (4934791..4942180, complement)

Chromosome 3 - NC_007089.4Genomic Context describing neighboring genes Neighboring gene BTB/POZ domain-containing protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene DUF254 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007089.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of TOR (target of rapamycin) inhibits cell proliferation in Dictyostelium discoideum. Swer PB, et al. J Basic Microbiol, 2016 May. PMID 26460541
  2. Caffeine inhibits PI3K and mTORC2 in Dictyostelium and differentially affects multiple other cAMP chemoattractant signaling effectors. Tariqul Islam AFM, et al. Mol Cell Biochem, 2019 Jul. PMID 30879206, Free PMC Article
  3. The small GTPases Ras and Rap1 bind to and control TORC2 activity. Khanna A, et al. Sci Rep, 2016 May 13. PMID 27172998, Free PMC Article
  4. Phosphorylated Rho-GDP directly activates mTORC2 kinase towards AKT through dimerization with Ras-GTP to regulate cell migration. Senoo H, et al. Nat Cell Biol, 2019 Jul. PMID 31263268, Free PMC Article
  5. TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Lee S, et al. Mol Biol Cell, 2005 Oct. PMID 16079174, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of asexual reproduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to caffeine IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Names
FRAP subfamily protein kinase
PIKK family protein kinase
phosphatidylinositol 3-kinase-related protein kinase
protein kinase, Atypical group

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007089.4 Reference assembly

    Range
    4934791..4942180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_635537.1 → XP_640629.1  protein kinase, Atypical group [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_640629.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q54TG2, Q86C65
    Conserved Domains (7) summary
    COG5032
    Location:244 → 2380
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd00020
    Location:624 → 735
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cd05169
    Location:1961 → 2239
    PIKKc_TOR; Catalytic domain of Target of Rapamycin
    pfam02260
    Location:2349 → 2380
    FATC; FATC domain
    pfam08771
    Location:1823 → 1919
    Rapamycin_bind; Rapamycin binding domain
    pfam11865
    Location:740 → 899
    DUF3385; Domain of unknown function (DUF3385)
    sd00044
    Location:501 → 524
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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