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PUP3 proteasome core particle subunit beta 3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856830, updated on 18-Sep-2024

Summary

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Official Symbol
PUP3
Official Full Name
proteasome core particle subunit beta 3
Primary source
SGD:S000000896
Locus tag
YER094C
See related
AllianceGenome:SGD:S000000896; FungiDB:YER094C; VEuPathDB:YER094C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SCS32
Summary
Enables endopeptidase activator activity. Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of proteasome core complex, beta-subunit complex. Used to study cancer. Orthologous to human PSMB3 (proteasome 20S subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (348729..349346, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene TORC2 complex subunit TSC11 Neighboring gene Aim11p Neighboring gene recombinase RAD51 Neighboring gene Shc1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic evidence for selective degradation of RNA polymerase subunits by the 20S proteasome in Saccharomyces cerevisiae. Nouraini S, et al. Nucleic Acids Res, 1997 Sep 15. PMID 9278475, Free PMC Article
  2. Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation. Arendt CS, et al. Proc Natl Acad Sci U S A, 1997 Jul 8. PMID 9207060, Free PMC Article
  3. Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1. Nussbaum AK, et al. Proc Natl Acad Sci U S A, 1998 Oct 13. PMID 9770515, Free PMC Article
  4. Proteasome beta-type subunits: unequal roles of propeptides in core particle maturation and a hierarchy of active site function. Jäger S, et al. J Mol Biol, 1999 Aug 27. PMID 10452902
  5. The catalytic sites of 20S proteasomes and their role in subunit maturation: a mutational and crystallographic study. Groll M, et al. Proc Natl Acad Sci U S A, 1999 Sep 28. PMID 10500111, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables endopeptidase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasomal ubiquitin-independent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasomal ubiquitin-independent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, beta-subunit complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex, beta-subunit complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
proteasome core particle subunit beta 3
NP_011020.3
  • Beta 3 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit C10

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    348729..349346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178985.3 → NP_011020.3  TPA: proteasome core particle subunit beta 3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011020.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM02, P25451
    UniProtKB/TrEMBL
    A6ZR51, B3LRL3, C7GRS8, C8Z7B3, G2WCY6, N1PA50
    Conserved Domains (1) summary
    cd03759
    Location:8 → 201
    proteasome_beta_type_3; proteasome beta type-3 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25451.1

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