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HSE1 ESCRT-0 subunit protein HSE1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856387, updated on 17-May-2024

Summary

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Gene symbol
HSE1
Gene description
ESCRT-0 subunit protein HSE1
Primary source
FungiDB:YHL002W
Locus tag
YHL002W
See related
SGD:S000000994; AllianceGenome:SGD:S000000994; VEuPathDB:YHL002W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ubiquitin binding activity. Involved in several processes, including ATP export; late endosome to vacuole transport; and protein targeting to vacuole. Located in endosome and vacuolar membrane. Part of ESCRT-0 complex. Orthologous to human STAM (signal transducing adaptor molecule) and STAM2 (signal transducing adaptor molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HSE1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (102612..103970)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein MRP4 Neighboring gene sphingosine N-acyltransferase LAG1 Neighboring gene ribosomal 60S subunit protein L14B Neighboring gene oxysterol-binding protein related protein OSH7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TORC1 regulates ESCRT-0 complex formation on the vacuolar membrane and microautophagy induction in yeast. Morshed S, et al. Biochem Biophys Res Commun, 2020 Jan 29. PMID 31740006
  2. Molecular determinants of the interaction between Doa1 and Hse1 involved in endosomal sorting. Han S, et al. Biochem Biophys Res Commun, 2014 Mar 28. PMID 24607902
  3. Evolution and origin of HRS, a protein interacting with Merlin, the Neurofibromatosis 2 gene product. Omelyanchuk LV, et al. Gene Regul Syst Bio, 2009 Oct 8. PMID 20054405, Free PMC Article
  4. The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting. Prag G, et al. Dev Cell, 2007 Jun. PMID 17543868, Free PMC Article
  5. Split Chloramphenicol Acetyl-Transferase Assay Reveals Self-Ubiquitylation-Dependent Regulation of UBE3B. Levin-Kravets O, et al. J Mol Biol, 2021 Nov 19. PMID 34599943

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TORC1 regulates ESCRT-0 complex formation on the vacuolar membrane and microautophagy induction in yeast.
    Title: TORC1 regulates ESCRT-0 complex formation on the vacuolar membrane and microautophagy induction in yeast.
  2. Small-angle X-ray scattering combined with molecular docking and biochemical analysis yield the solution structure of the Doa1/PFU:Hse1/SH3 complex and suggest that hydrogen bonding is a major determinant in the interaction of Doa1/PFU with Hse1/SH3.
    Title: Molecular determinants of the interaction between Doa1 and Hse1 involved in endosomal sorting.
  3. Endosomal Hse1-Vps27 sorting receptor binds to ubiquitin peptidases and the ubiquitin ligase Rsp5.
    Title: Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ATP export IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in late endosome to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuole IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ESCRT-0 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT-0 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ESCRT-0 subunit protein HSE1
NP_011861.1
  • Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    102612..103970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179082.1 → NP_011861.1  TPA: ESCRT-0 subunit protein HSE1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011861.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKR2, P38753
    UniProtKB/TrEMBL
    A0A8H4BZK6, A6ZSQ0, B3LSB6, C7GX96, C8ZA64, G2WF64, N1P2N8
    Conserved Domains (3) summary
    cd11805
    Location:221 → 273
    SH3_GRB2_like_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2 (GRB2) and related proteins
    cd16978
    Location:8 → 140
    VHS_HSE1; VHS (Vps27/Hrs/STAM) domain of Class E vacuolar protein-sorting machinery protein HSE1
    cd21386
    Location:290 → 374
    GAT_Hse1; non-canonical GAT domain found in fungal class E vacuolar protein-sorting machinery protein Hse1 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38753.1

Gene LinkOut

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