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UTP--glucose-1-phosphate uridylyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856374, updated on 18-Sep-2024

Summary

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Official Full Name
UTP--glucose-1-phosphate uridylyltransferase
Primary source
SGD:S000001004
Locus tag
YHL012W
See related
AllianceGenome:SGD:S000001004; FungiDB:YHL012W; VEuPathDB:YHL012W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable UTP:glucose-1-phosphate uridylyltransferase activity. Predicted to be involved in UDP-glucose metabolic process and glycogen metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (78936..80417)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Ylf2p Neighboring gene Otu2p Neighboring gene ribose phosphate diphosphokinase subunit PRS3 Neighboring gene Etp1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae VIG9 encodes GDP-mannose pyrophosphorylase, which is essential for protein glycosylation. Hashimoto H, et al. J Biol Chem, 1997 Jun 27. PMID 9195935
  2. Exposing the fitness contribution of duplicated genes. DeLuna A, et al. Nat Genet, 2008 May. PMID 18408719
  3. Multiple knockout analysis of genetic robustness in the yeast metabolic network. Deutscher D, et al. Nat Genet, 2006 Sep. PMID 16941010
  4. Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7. Logan MR, et al. BMC Genomics, 2008 Jul 15. PMID 18627629, Free PMC Article
  5. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Johnston M, et al. Science, 1994 Sep 30. PMID 8091229

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables UTP:glucose-1-phosphate uridylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UTP:glucose-1-phosphate uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in glycogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UTP--glucose-1-phosphate uridylyltransferase
NP_011851.1
  • Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    78936..80417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179092.1 → NP_011851.1  TPA: UTP--glucose-1-phosphate uridylyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011851.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKQ1, P38709
    UniProtKB/TrEMBL
    G2WF55
    Conserved Domains (1) summary
    COG4284
    Location:7 → 484
    QRI1; UDP-N-acetylglucosamine pyrophosphorylase [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38709.1

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