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MSS18 Mss18p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856253, updated on 18-Sep-2024

Summary

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Official Symbol
MSS18
Official Full Name
Mss18p
Primary source
SGD:S000006338
Locus tag
YPR134W
See related
AllianceGenome:SGD:S000006338; FungiDB:YPR134W; VEuPathDB:YPR134W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in Group I intron splicing and mitochondrial mRNA processing. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (798051..798857)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Spn1p Neighboring gene Tom5p Neighboring gene chromatin-binding protein CTF4 Neighboring gene Rrp9p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MSS18, a yeast nuclear gene involved in the splicing of intron aI5 beta of the mitochondrial cox1 transcript. Séraphin B, et al. EMBO J, 1988 May. PMID 2842150, Free PMC Article
  2. Mne1 is a novel component of the mitochondrial splicing apparatus responsible for processing of a COX1 group I intron in yeast. Watts T, et al. J Biol Chem, 2011 Mar 25. PMID 21257754, Free PMC Article
  3. Splicing of yeast aI5beta group I intron requires SUV3 to recycle MRS1 via mitochondrial degradosome-promoted decay of excised intron ribonucleoprotein (RNP). Turk EM, et al. J Biol Chem, 2010 Mar 19. PMID 20064926, Free PMC Article
  4. Multiple pathways influence mitochondrial inheritance in budding yeast. Frederick RL, et al. Genetics, 2008 Feb. PMID 18245340, Free PMC Article
  5. Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex. Vukotic M, et al. Cell Metab, 2012 Mar 7. PMID 22342701

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. defects in Suv3p result in accumulation of stable, excised group I intron ribonucleoproteins, which result in sequestration of Mrs1p, and a concomitant reduction in splicing of aI5beta
    Title: Splicing of yeast aI5beta group I intron requires SUV3 to recycle MRS1 via mitochondrial degradosome-promoted decay of excised intron ribonucleoprotein (RNP).
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Group I intron splicing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Group I intron splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial mRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mss18p
NP_015460.1
  • Nuclear encoded protein needed for splicing of mitochondrial intron; required for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    798051..798857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184231.1 → NP_015460.1  TPA: Mss18p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015460.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4D1, P08593
    UniProtKB/TrEMBL
    A6ZX12, B3LK96, B5VTS0, C8ZJF7, N1P2F0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08593.1

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