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BTS1 farnesyltranstransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856036, updated on 17-May-2024

Summary

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Gene symbol
BTS1
Gene description
farnesyltranstransferase
Primary source
FungiDB:YPL069C
Locus tag
YPL069C
See related
SGD:S000005990; AllianceGenome:SGD:S000005990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables farnesyltranstransferase activity. Involved in terpenoid biosynthetic process. Located in mitochondrion. Orthologous to human GGPS1 (geranylgeranyl diphosphate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BTS1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (422885..423892, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene guanine nucleotide exchange factor MUK1 Neighboring gene uncharacterized protein Neighboring gene Htc1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control activity of yeast geranylgeranyl diphosphate synthase from dimer interface through H-bonds and hydrophobic interaction. Chang CK, et al. Biochemistry, 2013 Apr 23. PMID 23534508
  2. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. Zhang Y, et al. J Am Chem Soc, 2009 Apr 15. PMID 19309137, Free PMC Article
  3. Effect of mutagenesis at the region upstream from the G(Q/E) motif of three types of geranylgeranyl diphosphate synthase on product chain-length. Noike M, et al. J Biosci Bioeng, 2009 Mar. PMID 19269584
  4. Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthase. Lo CH, et al. J Am Chem Soc, 2009 Mar 25. PMID 19245203
  5. Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases. Cao R, et al. Proteins, 2008 Nov 1. PMID 18442135, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. two amino acid residues in the first helix distal from the main dimer interface modulate the dimerization and activity of GGPP
    Title: Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dimethylallyltranstransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables farnesyltranstransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables farnesyltranstransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables geranyltranstransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables prenyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in farnesyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in geranyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in geranylgeranyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoprenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in terpenoid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in terpenoid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion HDA PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
farnesyltranstransferase
NP_015256.1
  • Geranylgeranyl diphosphate synthase (GGPPS); increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    422885..423892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183883.1 → NP_015256.1  TPA: farnesyltranstransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015256.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3U6, Q12051
    UniProtKB/TrEMBL
    A0A8H4F894, A6ZWI0, B3LL00, B5VT94, C7GTY8, C8ZIW1, G2WPB1, N1NVY0
    Conserved Domains (1) summary
    pfam00348
    Location:20 → 278
    polyprenyl_synt; Polyprenyl synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12051.1

Gene LinkOut

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