AVT4 Avt4p [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: AVT4
Gene description: Avt4p
Primary source: SGD:S000005045
Locus tag: YNL101W
See related: AllianceGenome:SGD:S000005045
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables L-glutamine transmembrane transporter activity; L-isoleucine transmembrane transporter activity; and L-tyrosine transmembrane transporter activity. Involved in amino acid transmembrane export from vacuole. Located in fungal-type vacuole membrane and vacuole-mitochondrion membrane contact site. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1) and SLC36A4 (solute carrier family 36 member 4). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Avt4p is a vacuolar amino acid exporter involving in the recycling of basic amino acids
Title: Vacuolar transporter Avt4 is involved in excretion of basic amino acids from the vacuoles of Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-glutamine transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables L-glutamine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-isoleucine transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables L-isoleucine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-tyrosine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-tyrosine transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables L-tyrosine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in L-alpha-amino acid transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in amino acid transmembrane export from vacuole	IGI Inferred from Genetic Interaction more info	PubMed
involved_in amino acid transmembrane export from vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in branched-chain amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in glutamine transport	IEA Inferred from Electronic Annotation more info
involved_in neutral amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in organic cation transport	IEA Inferred from Electronic Annotation more info
involved_in tyrosine transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in fungal-type vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in vacuolar membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info
located_in vacuole-mitochondrion membrane contact site	IDA Inferred from Direct Assay more info	PubMed

NP_014298.1

Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs)