IPI3 chromatin-binding/pre-rRNA-processing protein IPI3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: IPI3
Gene description: chromatin-binding/pre-rRNA-processing protein IPI3
Primary source: FungiDB:YNL182C
Locus tag: YNL182C
See related: SGD:S000005126; AllianceGenome:SGD:S000005126; VEuPathDB:YNL182C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables chromatin binding activity. Involved in pre-replicative complex assembly involved in nuclear cell cycle DNA replication; regulation of DNA-dependent DNA replication initiation; and ribosome biogenesis. Located in nucleoplasm. Part of Rix1 complex and nuclear pre-replicative complex. Orthologous to human WDR18 (WD repeat domain 18). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See IPI3 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (295960..297627, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study identified the Rix1 complex members (Ipi1p-Ipi2p/Rix1-Ipi3p) as pre-replicative complex components and critical determinants of replication licensing and replication-initiation frequency
Title: The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of nuclear pre-replicative complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pre-replicative complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of rixosome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of rixosome complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: chromatin-binding/pre-rRNA-processing protein IPI3

NP_014217.1

Component of the Rix1 complex and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene; other members include Rix1p, Ipi1p, and Ipi3p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

295960..297627 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183020.1 → NP_014217.1 TPA: chromatin-binding/pre-rRNA-processing protein IPI3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014217.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W104, P53877

UniProtKB/TrEMBL

A0A8H4FAQ5, B3LP32, B5VQM6, C7GTF5, C8ZG47, N1NXB1

Conserved Domains (2) summary

sd00039
Location:143 → 187

7WD40; WD40 repeat [structural motif]

cl29593
Location:108 → 226

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...