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GCV2 glycine decarboxylase subunit P [ Saccharomyces cerevisiae S288C ]

Gene ID: 855227, updated on 17-May-2024

Summary

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Gene symbol
GCV2
Gene description
glycine decarboxylase subunit P
Primary source
FungiDB:YMR189W
Locus tag
YMR189W
See related
SGD:S000004801; AllianceGenome:SGD:S000004801; VEuPathDB:YMR189W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GSD2
Summary
Enables glycine dehydrogenase (decarboxylating) activity. Involved in glycine decarboxylation via glycine cleavage system and one-carbon metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human GLDC (glycine decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GCV2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (637500..640604)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein MRPS17 Neighboring gene ATP-dependent DNA helicase SGS1 Neighboring gene Spg5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Specific induction by glycine of the gene for the P-subunit of glycine decarboxylase from Saccharomyces cerevisiae. Sinclair DA, et al. Mol Microbiol, 1996 Feb. PMID 8830251
  2. "Active" one-carbon generation in Saccharomyces cerevisiae. Ogur M, et al. J Bacteriol, 1977 Feb. PMID 320197, Free PMC Article
  3. Regulation of the yeast glycine cleavage genes is responsive to the availability of multiple nutrients. Piper MD, et al. FEMS Yeast Res, 2002 Mar. PMID 12702322
  4. Control of expression of one-carbon metabolism genes of Saccharomyces cerevisiae is mediated by a tetrahydrofolate-responsive protein binding to a glycine regulatory region including a core 5'-CTTCTT-3' motif. Hong SP, et al. J Biol Chem, 1999 Apr 9. PMID 10187845
  5. Identification of a novel one-carbon metabolism regulon in Saccharomyces cerevisiae. Gelling CL, et al. J Biol Chem, 2004 Feb 20. PMID 14645232

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine dehydrogenase (decarboxylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine dehydrogenase (decarboxylating) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycine dehydrogenase (decarboxylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in glycine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine decarboxylation via glycine cleavage system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine decarboxylation via glycine cleavage system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in one-carbon metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of glycine cleavage complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycine decarboxylase subunit P
NP_013914.1
  • P subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    637500..640604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182695.1 → NP_013914.1  TPA: glycine decarboxylase subunit P [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013914.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W013, P49095
    UniProtKB/TrEMBL
    A0A8H4F8C2, A6ZMQ0, C7GRG2, C8ZF53, N1P5R9
    Conserved Domains (1) summary
    TIGR00461
    Location:70 → 1023
    gcvP; glycine dehydrogenase (decarboxylating)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49095.1

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