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DAL7 malate synthase DAL7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854849, updated on 18-Sep-2024

Summary

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Official Symbol
DAL7
Official Full Name
malate synthase DAL7
Primary source
SGD:S000001470
Locus tag
YIR031C
See related
AllianceGenome:SGD:S000001470; FungiDB:YIR031C; VEuPathDB:YIR031C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MLS2; MSL2
Summary
Enables malate synthase activity. Involved in allantoin catabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DAL7 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (413015..414679, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene allantoicase Neighboring gene Dcg1p Neighboring gene ureidoglycolate hydrolase Neighboring gene Mga2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overlapping positive and negative GATA factor binding sites mediate inducible DAL7 gene expression in Saccharomyces cerevisiae. Rai R, et al. J Biol Chem, 1999 Sep 24. PMID 10488154
  2. Two structural genes are encoding malate synthase isoenzymes in Saccharomyces cerevisiae. Fernandez E, et al. FEBS Lett, 1993 Apr 12. PMID 8462696
  3. The DAL7 promoter consists of multiple elements that cooperatively mediate regulation of the gene's expression. Yoo HS, et al. Mol Cell Biol, 1989 Aug. PMID 2552287, Free PMC Article
  4. Differentially regulated malate synthase genes participate in carbon and nitrogen metabolism of S. cerevisiae. Hartig A, et al. Nucleic Acids Res, 1992 Nov 11. PMID 1454530, Free PMC Article
  5. A novel pathway to produce butanol and isobutanol in Saccharomyces cerevisiae. Branduardi P, et al. Biotechnol Biofuels, 2013 May 4. PMID 23642236, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables malate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables malate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables malate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables malate synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in allantoin catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glyoxylate cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glyoxylate cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 
is_active_in peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal matrix IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
malate synthase DAL7
NP_012297.3
  • Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    413015..414679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179553.3 → NP_012297.3  TPA: malate synthase DAL7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012297.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVW2, P21826
    UniProtKB/TrEMBL
    A6ZVV1, B3LTH8, C7GLS5, G2WFV9, N1P985
    Conserved Domains (1) summary
    TIGR01344
    Location:31 → 542
    malate_syn_A; malate synthase A
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21826.2

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