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SEC6 SNARE-binding exocyst subunit SEC6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854742, updated on 17-May-2024

Summary

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Gene symbol
SEC6
Gene description
SNARE-binding exocyst subunit SEC6
Primary source
FungiDB:YIL068C
Locus tag
YIL068C
See related
SGD:S000001330; AllianceGenome:SGD:S000001330; VEuPathDB:YIL068C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables SNARE binding activity. Involved in several processes, including Golgi to plasma membrane transport; exocyst localization; and negative regulation of SNARE complex assembly. Located in cellular bud neck and cellular bud tip. Part of exocyst. Orthologous to several human genes including EXOC3 (exocyst complex component 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SEC6 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (233057..235474, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Mam33p Neighboring gene ribosomal 40S subunit protein S24B Neighboring gene uncharacterized protein Neighboring gene ribonucleotide-diphosphate reductase subunit RNR3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles. Sivaram MV, et al. Nat Struct Mol Biol, 2006 Jun. PMID 16699513
  2. Characterization of the Saccharomyces cerevisiae sec6-4 mutation and tools to create S. cerevisiae strains containing the sec6-4 allele. Lamping E, et al. Gene, 2005 Nov 21. PMID 16185821
  3. ATP-dependent transport of organic anions in secretory vesicles of Saccharomyces cerevisiae. St-Pierre MV, et al. Proc Natl Acad Sci U S A, 1994 Sep 27. PMID 7937792, Free PMC Article
  4. Dimerization of the exocyst protein Sec6p and its interaction with the t-SNARE Sec9p. Sivaram MV, et al. Biochemistry, 2005 Apr 26. PMID 15835919
  5. SEC6 encodes an 85 kDa soluble protein required for exocytosis in yeast. Potenza M, et al. Yeast, 1992 Jul. PMID 1523887

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest a new model in which Sec6 promotes SNARE complex assembly, similar to the role proposed for other tether subunit-SNARE interactions
    Title: The Exocyst Subunit Sec6 Interacts with Assembled Exocytic SNARE Complexes.
  2. synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p
    Title: The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p.
  3. upon vesicle arrival, Sec6 is proposed to release Sec9 in favor of Sec6-exocyst assembly and to simultaneously recruit Sec1 to sites of secretion for coordinated SNARE complex formation and membrane fusion.
    Title: Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1.
  4. Sec6p is required to anchor exocyst complexes at sites of secretion.
    Title: Sec6p anchors the assembled exocyst complex at sites of secretion.
  5. residues 300-410 are necessary for dimerization, and the presence of the N-terminal region (1-299) increases dimer stability
    Title: Dimerization of the exocyst protein Sec6p and its interaction with the t-SNARE Sec9p.
  6. Study shows that the single point mutation L633P in the SEC6 coding region defines the sec6-4 mutation phenotype.
    Title: Characterization of the Saccharomyces cerevisiae sec6-4 mutation and tools to create S. cerevisiae strains containing the sec6-4 allele.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables SNARE binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Golgi to plasma membrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocyst localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocyst localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of SNARE complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of SNARE complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of SNARE complex assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst IDA
Inferred from Direct Assay
more info
 PubMed 
part_of exocyst IEA
Inferred from Electronic Annotation
more info
  
located_in mating projection tip HDA PubMed 
located_in prospore membrane HDA PubMed 

General protein information

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Preferred Names
SNARE-binding exocyst subunit SEC6
NP_012196.1
  • Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; binds to SNARE complexes binteracting with Sec9p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    233057..235474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179418.1 → NP_012196.1  TPA: SNARE-binding exocyst subunit SEC6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012196.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVL6, P32844
    UniProtKB/TrEMBL
    A0A6A5Q4Z0, A6ZVK5, B3LTS1, C7GVZ2, C8ZAH9, E9P8I5, G2WG80, N1P0Z7
    Conserved Domains (1) summary
    COG5173
    Location:2 → 805
    SEC6; Exocyst complex subunit SEC6 [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
5YFP_C.1
6VKL_C.1
P32844.2

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