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XBP1 Xbp1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854706, updated on 18-Sep-2024

Summary

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Official Symbol
XBP1
Official Full Name
Xbp1p
Primary source
SGD:S000001363
Locus tag
YIL101C
See related
AllianceGenome:SGD:S000001363; FungiDB:YIL101C; VEuPathDB:YIL101C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in cellular response to oxidative stress; negative regulation of transcription by RNA polymerase II; and positive regulation of histone deacetylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (175307..177250, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Thr Neighboring gene glucan 1,4-alpha-glucosidase Neighboring gene Fmc1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Xbp1, a stress-induced transcriptional repressor of the Saccharomyces cerevisiae Swi4/Mbp1 family. Mai B, et al. Mol Cell Biol, 1997 Nov. PMID 9343412, Free PMC Article
  2. Characterization of global gene expression during assurance of lifespan extension by caloric restriction in budding yeast. Choi KM, et al. Exp Gerontol, 2013 Dec. PMID 24126084
  3. CLN1 and its repression by Xbp1 are important for efficient sporulation in budding yeast. Mai B, et al. Mol Cell Biol, 2000 Jan. PMID 10611226, Free PMC Article
  4. Global Promoter Targeting of a Conserved Lysine Deacetylase for Transcriptional Shutoff during Quiescence Entry. McKnight JN, et al. Mol Cell, 2015 Sep 3. PMID 26300265, Free PMC Article
  5. Identification of target genes of a yeast transcriptional repressor. Mai B, et al. Methods Mol Biol, 2006. PMID 16264235

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Further global analysis revealed that Xbp1 represses 15% of all yeast genes as they enter the quiescent state and over 500 of these transcripts contain Xbp1 binding sites in their promoters
    Title: Xbp1 directs global repression of budding yeast transcription during the transition to quiescence and is important for the longevity and reversibility of the quiescent state.
  2. A role for Xbp1 in DSB repair via NHEJ through regulation of histone H4 acetylation.
    Title: Xbp1-mediated histone H4 deacetylation contributes to DNA double-strand break repair in yeast.
  3. the binding site for Xbp1 is present in the target genes of Swi4 and Mbp1 and is conserved phylogenetically
    Title: Identification of target genes of a yeast transcriptional repressor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding HDA PubMed 
enables transcription regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G1 to G0 transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to nitrogen starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MBF transcription complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SBF transcription complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Xbp1p
NP_012165.1
  • Transcriptional repressor; binds promoter sequences of cyclin genes, CYS3, and SMF2; not expressed during log phase of growth, but induced by stress or starvation during mitosis, and late in meiosis; represses 15% of all yeast genes as cells transition to quiescence; important for maintaining G1 arrest and for longevity of quiescent cells; member of Swi4p/Mbp1p family; phosphorylated by Cdc28p; relative distribution to nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    175307..177250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179449.1 → NP_012165.1  TPA: Xbp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012165.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVI7, P40489, Q12688
    UniProtKB/TrEMBL
    A6ZVH7, B3LTU7, C7GKM7, C8ZAE8, N1P0X1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40489.1

Gene LinkOut

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