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SWT1 mRNA-processing endoribonuclease [ Saccharomyces cerevisiae S288C ]

Gene ID: 854337, updated on 18-Sep-2024

Summary

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Official Symbol
SWT1
Official Full Name
mRNA-processing endoribonuclease
Primary source
SGD:S000005692
Locus tag
YOR166C
See related
AllianceGenome:SGD:S000005692; FungiDB:YOR166C; VEuPathDB:YOR166C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables endoribonuclease activity. Involved in nuclear mRNA surveillance of mRNP export and transcription elongation from RNA polymerase II promoter. Located in cytoplasm and nucleus. Orthologous to human SWT1 (SWT1 RNA endoribonuclease homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (647126..648502, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Get4p Neighboring gene dynamin-like GTPase SEY1 Neighboring gene ribosomal 40S subunit protein S28A Neighboring gene glutamine--tRNA ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-resolution crystal structure reveals a HEPN domain at the C-terminal region of S. cerevisiae RNA endonuclease Swt1. Peng S, et al. Biochem Biophys Res Commun, 2014 Oct 31. PMID 25450355
  2. The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. Bleichert F, et al. Proc Natl Acad Sci U S A, 2006 Jun 20. PMID 16769905, Free PMC Article
  3. Swt1, a novel yeast protein, functions in transcription. Röther S, et al. J Biol Chem, 2006 Dec 1. PMID 17030511
  4. Loss of Dfg5 glycosylphosphatidylinositol-anchored membrane protein confers enhanced heat tolerance in Saccharomyces cerevisiae. Nasution O, et al. Environ Microbiol, 2015 Aug. PMID 25297926
  5. An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes. Skruzný M, et al. PLoS Biol, 2009 Jan 6. PMID 19127978, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Swt1 functions in gene expression in conjunction with the TREX complex
    Title: Swt1, a novel yeast protein, functions in transcription.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA endonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nuclear mRNA surveillance of mRNP export IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mRNA-processing endoribonuclease
NP_014809.3
  • RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    647126..648502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183585.3 → NP_014809.3  TPA: mRNA-processing endoribonuclease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014809.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2M4, Q12104
    UniProtKB/TrEMBL
    A6ZP11, B3LJJ9, B5VS53, C7GN58, C8ZGS7, N1NWP8
    Conserved Domains (1) summary
    cd18727
    Location:133 → 280
    PIN_Swt1-like; VapC-like PIN domain of Saccharomyces cerevisiae Swt1p, human SWT1 and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12104.1

Gene LinkOut

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