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ARP8 Arp8p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854309, updated on 18-Sep-2024

Summary

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Official Symbol
ARP8
Official Full Name
Arp8p
Primary source
SGD:S000005667
Locus tag
YOR141C
See related
AllianceGenome:SGD:S000005667; FungiDB:YOR141C; VEuPathDB:YOR141C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Involved in chromatin remodeling; double-strand break repair; and mitotic recombination. Located in nucleus. Part of Ino80 complex. Orthologous to human ACTR8 (actin related protein 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ARP8 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (589942..592587, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rup1p Neighboring gene Sfl1p Neighboring gene succinate--CoA ligase (GDP-forming) subunit alpha Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exploring the functional landscape of gene expression: directed search of large microarray compendia. Hibbs MA, et al. Bioinformatics, 2007 Oct 15. PMID 17724061
  2. Effect of nuclear architecture on the efficiency of double-strand break repair. Agmon N, et al. Nat Cell Biol, 2013 Jun. PMID 23644470
  3. Targeted INO80 enhances subnuclear chromatin movement and ectopic homologous recombination. Neumann FR, et al. Genes Dev, 2012 Feb 15. PMID 22345518, Free PMC Article
  4. Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin. Fenn S, et al. EMBO J, 2011 Jun 1. PMID 21499228, Free PMC Article
  5. The INO80 chromatin remodeling complex functions in sister chromatid cohesion. Ogiwara H, et al. Cell Cycle, 2007 May 2. PMID 17471029

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arp8 engages N-actin in a manner distinct from that of other actin-fold proteins and thereby specifies recruitment of the Arp4-N-actin heterodimer to a segmented scaffold of the helicase-SANT-associated (HSA) domain of Ino80
    Title: The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling.
  2. Interactions between the nucleosome histone core and Arp8 in the INO80 chromatin remodeling complex
    Title: Interactions between the nucleosome histone core and Arp8 in the INO80 chromatin remodeling complex.
  3. Remarkably, Arp4, assisted by Arp8, influences actin polymerization in vitro and is able to depolymerize actin filaments.
    Title: Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ino80 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular non-membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Arp8p
NP_014784.1
  • Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    589942..592587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183560.1 → NP_014784.1  TPA: Arp8p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014784.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2J7, Q12386
    UniProtKB/TrEMBL
    G2WN14
    Conserved Domains (2) summary
    smart00268
    Location:266 → 878
    ACTIN; Actin
    cl17037
    Location:42 → 447
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12386.1

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