RTS1 protein phosphatase 2A regulatory subunit RTS1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RTS1
Official Full Name: protein phosphatase 2A regulatory subunit RTS1
Primary source: SGD:S000005540
Locus tag: YOR014W
See related: AllianceGenome:SGD:S000005540; FungiDB:YOR014W; VEuPathDB:YOR014W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SCS1
Summary: Enables DNA binding activity and protein phosphatase regulator activity. Involved in several processes, including mitotic spindle orientation checkpoint signaling; septin ring organization; and sister chromatid segregation. Located in several cellular components, including cellular bud neck; kinetochore; and spindle pole body. Colocalizes with chromosome, centromeric region. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 35. Orthologous to several human genes including PPP2R5C (protein phosphatase 2 regulatory subunit B'gamma). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RTS1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (357674..359947)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PP2A(Rts1) antagonizes Rck2-mediated hyperosmotic stress signaling in yeast.
Title: PP2A(Rts1) antagonizes Rck2-mediated hyperosmotic stress signaling in yeast.
Cdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit.
Title: Cdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit.
Here, we show that Rts1 is required for the proportional relationship between cell size and growth rate during mitosis. Moreover, nutrients and Rts1 influence the duration and extent of growth in mitosis via Wee1 and Pds1/securin, two conserved regulators of mitotic progression.
Title: A Conserved PP2A Regulatory Subunit Enforces Proportional Relationships Between Cell Size and Growth Rate.
orchestrated action of PP2A antagonizes Atg13 phosphorylation and promotes autophagy after the inactivation of TORC1
Title: Orchestrated Action of PP2A Antagonizes Atg13 Phosphorylation and Promotes Autophagy after the Inactivation of TORC1.
We find that RTS1, one of two genes encoding PP2A regulatory subunits, is a robust and specific high-copy suppressor of temperature sensitivity of gcn5 and a subset of other gcn5 phenotypes
Title: Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae.
rts1Delta mutants exhibited premature spindle assembly checkpoint silencing.
Title: Premature Silencing of the Spindle Assembly Checkpoint Is Prevented by the Bub1-H2A-Sgo1-PP2A Axis in Saccharomyces cerevisiae.
Ptp1 and PP2ARts1 work redundantly with Mih1 to regulate Cdk1-Y19 dephosphorylation
Title: Redundant Regulation of Cdk1 Tyrosine Dephosphorylation in Saccharomyces cerevisiae.
Data show that mutation of the Rts1 regulatory subunit of PP2A phosphatase (PP2ARts1 phosphatase) results in decreased HO endonuclease expression due to altered localization of the Ace2 transcription factor.
Title: The Rts1 regulatory subunit of PP2A phosphatase controls expression of the HO endonuclease via localization of the Ace2 transcription factor.
Rts1 constitutively directs protein phosphatase 2A activity toward the prodomain, effectively setting a signaling threshold required to mute Ssy5 activation.
Title: Rts1-protein phosphatase 2A antagonizes Ptr3-mediated activation of the signaling protease Ssy5 by casein kinase I.
Loss of PP2A-Rts1 function abrogates the SPOC but not other mitotic checkpoints
Title: The protein phosphatase 2A functions in the spindle position checkpoint by regulating the checkpoint kinase Kin4.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular bud neck septin ring organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular bud neck septin ring organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization to chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic sister chromatid cohesion, centromeric	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle orientation checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of autophagosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septin ring disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in sister chromatid biorientation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase type 2A complex	IEA Inferred from Electronic Annotation more info
located_in spindle pole body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein phosphatase 2A regulatory subunit RTS1

NP_014657.1

B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

357674..359947

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183433.1 → NP_014657.1 TPA: protein phosphatase 2A regulatory subunit RTS1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014657.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W281, P38903

UniProtKB/TrEMBL

A6ZNL9, C7GLE5, C8ZHX8, G2WMP5

Conserved Domains (1) summary

pfam01603
Location:284 → 710

B56; Protein phosphatase 2A regulatory B subunit (B56 family)