U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NUP192 Nup192p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853410, updated on 17-May-2024

Summary

Go to the top of the page Help
Gene symbol
NUP192
Gene description
Nup192p
Primary source
FungiDB:YJL039C
Locus tag
YJL039C
See related
SGD:S000003576; AllianceGenome:SGD:S000003576; VEuPathDB:YJL039C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
A structural constituent of nuclear pore. Involved in nuclear pore organization and regulation of nucleocytoplasmic transport. Located in nucleus. Part of nuclear pore inner ring. Human ortholog(s) of this gene implicated in nephrotic syndrome type 13. Orthologous to human NUP205 (nucleoporin 205). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NUP192 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (368748..373799, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Mhp1p Neighboring gene FG-nucleoporin NSP1 Neighboring gene tRNA-Asp Neighboring gene tRNA-Arg

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex. Li Z, et al. Cell Res, 2022 May. PMID 35301440, Free PMC Article
  2. Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors. Andersen KR, et al. Elife, 2013 Jun 11. PMID 23795296, Free PMC Article
  3. Structure, dynamics, evolution, and function of a major scaffold component in the nuclear pore complex. Sampathkumar P, et al. Structure, 2013 Apr 2. PMID 23499021, Free PMC Article
  4. Yeast nuclear pore complex assembly defects determined by nuclear envelope reconstruction. Gomez-Ospina N, et al. J Struct Biol, 2000 Oct. PMID 11121302
  5. Nup192p is a conserved nucleoporin with a preferential location at the inner site of the nuclear membrane. Kosova B, et al. J Biol Chem, 1999 Aug 6. PMID 10428845

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. both Nup188 and Nup192 specifically bind FG-repeats and are able to translocate through NPCs by facilitated diffusion
    Title: Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear pore organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear pore organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore inner ring IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore inner ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Nup192p
NP_012495.1
  • Essential subunit of inner ring of nuclear pore complex (NPC); plays a role in modulating transport through the NPC; homologous to human NUP205

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    368748..373799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181473.1 → NP_012495.1  TPA: Nup192p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012495.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWE4, P47054
    UniProtKB/TrEMBL
    A0A8H4BZK9, A6ZPT7, G2WGX9, N1P0X2
    Conserved Domains (1) summary
    pfam11894
    Location:134 → 1677
    Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47054.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous