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FAR1 cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853283, updated on 18-Sep-2024

Summary

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Official Symbol
FAR1
Official Full Name
cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1
Primary source
SGD:S000003693
Locus tag
YJL157C
See related
AllianceGenome:SGD:S000003693; FungiDB:YJL157C; VEuPathDB:YJL157C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in chemotropism; maintenance of protein location in nucleus; and mitotic cell cycle G1 arrest in response to pheromone. Located in cytoplasm; mating projection tip; and nucleus. Part of Cdc24p-Far1p-Gbetagamma complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (123836..126328, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene heat shock protein HSP150 Neighboring gene Cis3p Neighboring gene Ssy5p Neighboring gene fructose-2,6-bisphosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Negative regulation of FAR1 at the Start of the yeast cell cycle. McKinney JD, et al. Genes Dev, 1993 May. PMID 8491380
  2. FAR1 is required for posttranscriptional regulation of CLN2 gene expression in response to mating pheromone. Valdivieso MH, et al. Mol Cell Biol, 1993 Feb. PMID 8423774, Free PMC Article
  3. FAR1 and the G1 phase specificity of cell cycle arrest by mating factor in Saccharomyces cerevisiae. McKinney JD, et al. Mol Cell Biol, 1995 May. PMID 7739534, Free PMC Article
  4. FAR1 is required for oriented polarization of yeast cells in response to mating pheromones. Valtz N, et al. J Cell Biol, 1995 Nov. PMID 7490290, Free PMC Article
  5. Phosphorylation of FAR1 in response to alpha-factor: a possible requirement for cell-cycle arrest. Chang F, et al. Mol Biol Cell, 1992 Apr. PMID 1498364, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This papers suggests that Far1 engages the cyclin-Cdk complex in a way that disrupts multiple distinct functions, including both substrate docking and kinase activity but perhaps also others such as Cks1-mediated processivity.
    Title: Regulation of cyclin-substrate docking by a G1 arrest signaling pathway and the Cdk inhibitor Far1.
  2. Studied FAR1 overexpression, which not only coordinately increases RNA and protein accumulation, but induces strong transcriptional remodeling.
    Title: Overexpression of Far1, a cyclin-dependent kinase inhibitor, induces a large transcriptional reprogramming in which RNA synthesis senses Far1 in a Sfp1-mediated way.
  3. Cln3 must overcome Far1 to trigger Cln-Cdc28 activation, which then turns on transcription; a second threshold is required together with the Cln3/Far1 threshold for carbon source modulation of protein content per cell at the onset of DNA replication
    Title: A cell sizer network involving Cln3 and Far1 controls entrance into S phase in the mitotic cycle of budding yeast.
  4. Gbetagamma not only targets Far1p to the correct site but may also trigger a conformational change in Far1p that is required for its ability to activate Cdc24p in vivo
    Title: Site-specific regulation of the GEF Cdc24p by the scaffold protein Far1p during yeast mating.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotropism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of protein location in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle G1 arrest in response to pheromone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to pheromone triggering conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cdc24p-Far1p-Gbetagamma complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Cdc24p-Far1p-Gbetagamma complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1
NP_012378.1
  • CDK inhibitor and nuclear anchor; during the cell cycle Far1p sequesters the GEF Cdc24p in the nucleus; phosphorylation by Cdc28p-Cln results in SCFCdc4 complex-mediated ubiquitin-dependent degradation, releasing Cdc24p for export and activation of GTPase Cdc42p; in response to pheromone, phosphorylation of Far1p by MAPK Fus3p results in association with, and inhibition of Cdc28p-Cln, as well as Msn5p mediated nuclear export of Far1p-Cdc24p, targeting Cdc24p to polarity sites

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    123836..126328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181590.1 → NP_012378.1  TPA: cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012378.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW30, P21268
    UniProtKB/TrEMBL
    G2WGL6
    Conserved Domains (1) summary
    smart00184
    Location:202 → 251
    RING; Ring finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21268.2

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