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CEG1 mRNA guanylyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852747, updated on 11-Apr-2024

Summary

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Gene symbol
CEG1
Gene description
mRNA guanylyltransferase
Primary source
SGD:S000003098
Locus tag
YGL130W
See related
AllianceGenome:SGD:S000003098
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA guanylyltransferase activity. Involved in 7-methylguanosine mRNA capping; positive regulation of transcription by RNA polymerase II; and tRNA processing. Located in nucleus. Part of mRNA cap methyltransferase complex. Orthologous to human RNGTT (RNA guanylyltransferase and 5'-phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (266145..267524)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Itc1p Neighboring gene DNA-binding E3 ubiquitin-protein ligase SNT2 Neighboring gene mitochondrial 37S ribosomal protein RSM23 Neighboring gene U2-type spliceosomal complex subunit CWC23

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Virtual high-throughput screening identifies mycophenolic acid as a novel RNA capping inhibitor. Tremblay-Létourneau M, et al. PLoS One, 2011. PMID 21935470, Free PMC Article
  2. Thermodynamics of ligand binding by the yeast mRNA-capping enzyme reveals different modes of binding. Bougie I, et al. Biochem J, 2004 Dec 1. PMID 15307816, Free PMC Article
  3. Phylogeny of mRNA capping enzymes. Wang SP, et al. Proc Natl Acad Sci U S A, 1997 Sep 2. PMID 9275164, Free PMC Article
  4. Localization and in vitro mutagenesis of the active site in the Saccharomyces cerevisiae mRNA capping enzyme. Shibagaki Y, et al. J Biochem, 1995 Dec. PMID 8720151
  5. Conditional mutants of the yeast mRNA capping enzyme show that the cap enhances, but is not required for, mRNA splicing. Fresco LD, et al. RNA, 1996 Jun. PMID 8718687, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ceg1 depletion reveals mechanisms governing degradation of non-capped RNAs in Saccharomyces cerevisiae.
    Title: Ceg1 depletion reveals mechanisms governing degradation of non-capped RNAs in Saccharomyces cerevisiae.
  2. analysis of the role of the Ceg1-carboxy terminal domain interaction in mRNA transcription
    Title: The mRNA capping enzyme of Saccharomyces cerevisiae has dual specificity to interact with CTD of RNA Polymerase II.
  3. The results indicate that the Cet1p-Ceg1p interaction is important not only for the activation of Ceg1p, but also for nuclear import of the complex.
    Title: The essential role for the RNA triphosphatase Cet1p in nuclear import of the mRNA capping enzyme Cet1p-Ceg1p complex of Saccharomyces cerevisiae.
  4. Data show that the early Pol II elongation factor Spt5 contributes to stable recruitment of the mRNA capping enzymes Cet1, Ceg1, and Abd1 in the initiation-elongation transition of RNA polymerase II.
    Title: Cap completion and C-terminal repeat domain kinase recruitment underlie the initiation-elongation transition of RNA polymerase II.
  5. A crystal structure of Cet1-Ceg1 revealed a 176 kDa heterotetrameric complex composed of one Cet1 homodimer that associates with two Ceg1 molecules via interactions between the Ceg1 oligonucleotide binding domain and an extended Cet1 amino acid motif.
    Title: Structure of the Saccharomyces cerevisiae Cet1-Ceg1 mRNA capping apparatus.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA guanylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA guanylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA guanylyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 7-methylguanosine mRNA capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 7-methylguanosine mRNA capping IEA
Inferred from Electronic Annotation
more info
  
involved_in 7-methylguanosine mRNA capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of mRNA capping enzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of mRNA capping enzyme complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of mRNA capping enzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
mRNA guanylyltransferase
NP_011385.3
  • Guanylyltransferase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of two molecules of Ceg1p and a homodimer of Cet1p, the mRNA 5'-triphosphatase subunit; nuclear import of Ceg1p requires interaction with Cet1p; mammalian capping enzyme is a single bifunctional polypeptide; human homolog RNGTT can complement yeast ceg1 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    266145..267524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180995.3 → NP_011385.3  TPA: mRNA guanylyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011385.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU18, Q01159, Q9URD1
    UniProtKB/TrEMBL
    A0A8H4FCU0, A6ZU52, B3LHI9, B5VIJ9, C7GX64, C8Z8C0, G2WDX2, N1P3E0
    Conserved Domains (1) summary
    COG5226
    Location:1 → 449
    CEG1; mRNA capping enzyme, guanylyltransferase (alpha) subunit [RNA processing and modification]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01159.2

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