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QDR3 Qdr3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852331, updated on 18-Sep-2024

Summary

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Official Symbol
QDR3
Official Full Name
Qdr3p
Primary source
SGD:S000000247
Locus tag
YBR043C
See related
AllianceGenome:SGD:S000000247; FungiDB:YBR043C; VEuPathDB:YBR043C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AQR2
Summary
Enables efflux transmembrane transporter activity and polyamine transmembrane transporter activity. Involved in ascospore wall assembly; polyamine homeostasis; and transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (321876..323945, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene long-chain fatty acid transporter FAT1 Neighboring gene putative acyltransferase Neighboring gene Tcm62p Neighboring gene tRNA-Val

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast cells with impaired drug resistance accumulate glycerol and glucose. Dikicioglu D, et al. Mol Biosyst, 2014 Jan. PMID 24157722
  2. Overlapping Roles of Yeast Transporters Aqr1, Qdr2, and Qdr3 in Amino Acid Excretion and Cross-Feeding of Lactic Acid Bacteria. Kapetanakis GC, et al. Front Microbiol, 2021. PMID 34887841, Free PMC Article
  3. Improvement of acetic acid tolerance of Saccharomyces cerevisiae using a zinc-finger-based artificial transcription factor and identification of novel genes involved in acetic acid tolerance. Ma C, et al. Appl Microbiol Biotechnol, 2015 Mar. PMID 25698512
  4. The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycin. Tenreiro S, et al. Biochem Biophys Res Commun, 2005 Feb 18. PMID 15649438
  5. Yeast response and tolerance to polyamine toxicity involving the drug : H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4. Teixeira MC, et al. Microbiology (Reading), 2011 Apr. PMID 21148207

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables efflux transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables polyamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polyamine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables threonine efflux transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ascospore wall assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular polyamine homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular polyamine homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polyamine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in threonine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Qdr3p
NP_009599.2
  • Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; involved in spore wall asembly; sequence similarity to DTR1 and QDR1, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    321876..323945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178391.2 → NP_009599.2  TPA: Qdr3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009599.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ43, P38227
    UniProtKB/TrEMBL
    C7GXW9, D3UED8, N1P6G2
    Conserved Domains (1) summary
    cd17323
    Location:110 → 676
    MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38227.2

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