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SRF1 Srf1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851423, updated on 18-Sep-2024

Summary

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Official Symbol
SRF1
Official Full Name
Srf1p
Primary source
SGD:S000002291
Locus tag
YDL133W
See related
AllianceGenome:SGD:S000002291; FungiDB:YDL133W; VEuPathDB:YDL133W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in positive regulation of catalytic activity. Located in cell periphery and fungal-type vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (222427..223740)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene phosphoprotein phosphatase 2A catalytic subunit PPH21 Neighboring gene ribosomal 60S subunit protein L41B Neighboring gene cullin CDC53 Neighboring gene homocitrate synthase LYS21

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor. Kennedy MA, et al. PLoS Genet, 2011 Feb 10. PMID 21347278, Free PMC Article
  2. Fig1p facilitates Ca2+ influx and cell fusion during mating of Saccharomyces cerevisiae. Muller EM, et al. J Biol Chem, 2003 Oct 3. PMID 12878605
  3. The oxysterol binding protein Kes1p regulates Golgi apparatus phosphatidylinositol-4-phosphate function. Fairn GD, et al. Proc Natl Acad Sci U S A, 2007 Sep 25. PMID 17881569, Free PMC Article
  4. Saccharomyces cerevisiae S288C genome annotation: a working hypothesis. Fisk DG, et al. Yeast, 2006 Sep. PMID 17001629, Free PMC Article
  5. A nuclear role for the DEAD-box protein Dbp5 in tRNA export. Lari A, et al. Elife, 2019 Aug 27. PMID 31453808, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of YDL133w, a previously uncharacterized gene here renamed SRF1 (Spo14 Regulatory Factor 1), resulted in the greatest differential sensitivity to C16:0 PAF over C16:0 lyso-PAF.
    Title: Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Srf1p
NP_010149.1
  • Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    222427..223740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180192.1 → NP_010149.1  TPA: Srf1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010149.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRL6, P89897, Q12516, Q7LGS2
    UniProtKB/TrEMBL
    A6ZXJ5, B5VFD7, C7GSS8, G2WC28, N1P7J2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12516.1

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