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KIN2 serine/threonine protein kinase KIN2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850785, updated on 17-May-2024

Summary

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Gene symbol
KIN2
Gene description
serine/threonine protein kinase KIN2
Primary source
FungiDB:YLR096W
Locus tag
YLR096W
See related
SGD:S000004086; AllianceGenome:SGD:S000004086; VEuPathDB:YLR096W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine kinase activity. Involved in positive regulation of IRE1-mediated unfolded protein response; positive regulation of exocytosis; and protein phosphorylation. Located in cellular bud neck; cellular bud tip; and plasma membrane. Orthologous to human SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See KIN2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (332590..336033)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Gis3p Neighboring gene Ioc2p Neighboring gene SCF ubiquitin ligase complex subunit HRT3 Neighboring gene Cha4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the KIN2 gene product in Saccharomyces cerevisiae and comparison between the kinase activities of p145KIN1 and p145KIN2. Donovan M, et al. Yeast, 1994 Jan. PMID 8203145
  2. KIN1 and KIN2 protein kinases localize to the cytoplasmic face of the yeast plasma membrane. Tibbetts M, et al. Exp Cell Res, 1994 Jul. PMID 8020610
  3. Two yeast genes that encode unusual protein kinases. Levin DE, et al. Proc Natl Acad Sci U S A, 1987 Sep. PMID 2957690, Free PMC Article
  4. A putative protein kinase gene (kin1+) is important for growth polarity in Schizosaccharomyces pombe. Levin DE, et al. Proc Natl Acad Sci U S A, 1990 Nov. PMID 2236039, Free PMC Article
  5. A novel role for protein kinase Kin2 in regulating HAC1 mRNA translocation, splicing, and translation. Anshu A, et al. Mol Cell Biol, 2015 Jan. PMID 25348718, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast.
    Title: Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast.
  2. Recognition of phosphorylated substrates by Kin1/Kin2 was mediated by a patch of basic residues located in the region of the kinase alphaC helix.
    Title: Substrate priming enhances phosphorylation by the budding yeast kinases Kin1 and Kin2.
  3. Overexpression of Kin2 affects septin organization and cell wall.
    Title: Kin2, the Budding Yeast Ortholog of Animal MARK/PAR-1 Kinases, Localizes to the Sites of Polarized Growth and May Regulate Septin Organization and the Cell Wall.
  4. Kin2 has a role in regulating HAC1 mRNA translocation, splicing, and translation
    Title: A novel role for protein kinase Kin2 in regulating HAC1 mRNA translocation, splicing, and translation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of IRE1-mediated unfolded protein response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of exocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of exocytosis IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine protein kinase KIN2
NP_013197.1
  • S/T protein kinase; regulates polarized exocytosis and the Ire1p-mediated UPR; regulates HAC1 mRNA translocation, splicing and translation with KIN1 during ER stress; direct phosphorylation of Sec9p (S190) is enhanced by prior substrate priming (S192); localizes to the cytoplasmic face of the PM and sites of polarized growth; may regulate septin and cell wall organization; activation loop phosphorylation (T281) required for full kinase activity; orthologous to MARK/PAR-1, AMPK family members

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    332590..336033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181983.1 → NP_013197.1  TPA: serine/threonine protein kinase KIN2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013197.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY96, P13186, Q12384
    UniProtKB/TrEMBL
    A0A8H4BX48, B3LT64, B5VN32, C7GQR9, C8ZD66, N1NZ79
    Conserved Domains (2) summary
    cd14077
    Location:97 → 377
    STKc_Kin1_2; Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases
    pfam02149
    Location:1104 → 1147
    KA1; Kinase associated domain 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13186.3

Gene LinkOut

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