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GNA1 glucosamine 6-phosphate N-acetyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850529, updated on 13-Apr-2024

Summary

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Gene symbol
GNA1
Gene description
glucosamine 6-phosphate N-acetyltransferase
Primary source
SGD:S000001877
Locus tag
YFL017C
See related
AllianceGenome:SGD:S000001877
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PAT1
Summary
Enables glucosamine 6-phosphate N-acetyltransferase activity. Involved in UDP-N-acetylglucosamine biosynthetic process. Located in cytoplasm and nucleus. Used to study cancer and keratosis follicularis spinulosa decalvans. Orthologous to human GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (103983..104462, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene dihydrolipoyl dehydrogenase Neighboring gene mRNA splicing protein SMX2 Neighboring gene Mdj1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modular pathway engineering of Bacillus subtilis for improved N-acetylglucosamine production. Liu Y, et al. Metab Eng, 2014 May. PMID 24560814
  2. The crystal structures of Apo and complexed Saccharomyces cerevisiae GNA1 shed light on the catalytic mechanism of an amino-sugar N-acetyltransferase. Peneff C, et al. J Biol Chem, 2001 May 11. PMID 11278591
  3. PAT1, an evolutionarily conserved acetyltransferase homologue, is required for multiple steps in the cell cycle. Lin R, et al. Genes Cells, 1996 Oct. PMID 9077451
  4. Saccharomyces cerevisiae GNA1, an essential gene encoding a novel acetyltransferase involved in UDP-N-acetylglucosamine synthesis. Mio T, et al. J Biol Chem, 1999 Jan 1. PMID 9867860
  5. The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae. Alme EB, et al. PLoS Genet, 2020 Jun. PMID 32579556, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables glucosamine 6-phosphate N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosamine 6-phosphate N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucosamine 6-phosphate N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UDP-N-acetylglucosamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UDP-N-acetylglucosamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
glucosamine 6-phosphate N-acetyltransferase
NP_116637.1
  • Glucosamine-6-phosphate acetyltransferase; evolutionarily conserved; required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    103983..104462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179949.1 → NP_116637.1  TPA: glucosamine 6-phosphate N-acetyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116637.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTL3, P43577
    UniProtKB/TrEMBL
    A0A6A5PWK9, A7A222, G2WDC4, N1P4L7
    Conserved Domains (1) summary
    cl17182
    Location:5 → 155
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43577.1

Gene LinkOut

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