U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PDIL1-2 PDI-like 1-2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 844087, updated on 7-Sep-2023

Summary

Go to the top of the page Help
Gene symbol
PDIL1-2
Gene description
PDI-like 1-2
Primary source
Araport:AT1G77510
Locus tag
AT1G77510
See related
TAIR:AT1G77510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATPDI6; ATPDIL1-2; PDI-like 1-2; PDI6; PROTEIN DISULFIDE ISOMERASE 6; T5M16.10; T5M16_10
Summary
Encodes a protein disulfide isomerase-like (PDIL) protein, a member of a multigene family within the thioredoxin (TRX) superfamily. Transcript levels for this gene are up-regulated in response to three different chemical inducers of ER stress (dithiothreitol, beta-mercaptoethanol, and tunicamycin). AtIRE1-2 does not appear to be required for this response, but the atbzip60 mutant has a diminished response. This protein has been shown to be an attenuator of D1 synthesis, modulating photoinhibition in a light-regulated manner.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PDIL1-2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Sequence:
Chromosome: 1; NC_003070.9 (29126648..29129700)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene thylakoidal ascorbate peroxidase Neighboring gene DUF630 family protein, putative (DUF630 and DUF632) Neighboring gene O-methyltransferase family protein Neighboring gene defensin-like protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Knockdown of the Arabidopsis thaliana chloroplast protein disulfide isomerase 6 results in reduced levels of photoinhibition and increased D1 synthesis in high light. Wittenberg G, et al. Plant J, 2014 Jun. PMID 24684167
  2. Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana. Lu DP, et al. Mol Genet Genomics, 2008 Sep. PMID 18574595
  3. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
  4. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
  5. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AtPDI6 is an attenuator of D1 synthesis, modulating photoinhibition in a light-regulated manner.
    Title: Knockdown of the Arabidopsis thaliana chloroplast protein disulfide isomerase 6 results in reduced levels of photoinhibition and increased D1 synthesis in high light.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

NM_106400.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein disulfide isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein disulfide isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within photoinhibition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to endoplasmic reticulum stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to high light intensity IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in secretory vesicle HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
PDI-like 1-2
NP_177875.1
  • PDI-like 1-2 (PDIL1-2); FUNCTIONS IN: protein disulfide isomerase activity; INVOLVED IN: response to cadmium ion, response to salt stress, response to endoplasmic reticulum stress; LOCATED IN: endoplasmic reticulum, plasma membrane, chloroplast; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Disulphide isomerase (InterPro:IPR005788), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin-like subdomain (InterPro:IPR006662), Protein disulphide isomerase (InterPro:IPR005792), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: PDI-like 1-1 (TAIR:AT1G21750.1); Has 30299 Blast hits to 17128 proteins in 2902 species: Archae - 354; Bacteria - 14610; Metazoa - 5224; Fungi - 1567; Plants - 2445; Viruses - 29; Other Eukaryotes - 6070 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    29126648..29129700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_106400.3 → NP_177875.1  PDI-like 1-2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_177875.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WV97, Q9SRG3
    UniProtKB/TrEMBL
    A0A178W930, A0A5S9WV75
    Conserved Domains (1) summary
    TIGR01130
    Location:29 → 481
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SRG3.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools