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HMG1 hydroxy methylglutaryl CoA reductase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 843982, updated on 18-Sep-2024

Summary

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Official Symbol
HMG1
Official Full Name
hydroxy methylglutaryl CoA reductase 1
Primary source
TAIR:AT1G76490
Locus tag
AT1G76490
See related
Araport:AT1G76490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
3-HYDROXY-3-METHYLGLUTARYL COA REDUCTASE; 3-HYDROXY-3-METHYLGLUTARYL COA REDUCTASE 1; AtHMGR1; F15M4.1; HMG-COA REDUCTASE; HMGR1; hydroxy methylglutaryl CoA reductase 1; MAD3; miRNA action deficient 3
Summary
Encodes a 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is involved in melavonate biosynthesis and performs the first committed step in isoprenoid biosynthesis. Expression is activated in dark in leaf tissue but not controlled by light in the root (confine
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Genomic context

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Location:
chromosome: 1
Exon count:
4
Sequence:
Chromosome: 1; NC_003070.9 (28695760..28698852)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene caveolin-1 protein Neighboring gene Putative AT-hook DNA-binding family protein Neighboring gene ARID/BRIGHT DNA-binding domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proliferation and Morphogenesis of the Endoplasmic Reticulum Driven by the Membrane Domain of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Plant Cells. Ferrero S, et al. Plant Physiol, 2015 Jul. PMID 26015445, Free PMC Article
  2. Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia. Muñoz-Bertomeu J, et al. Plant Biotechnol J, 2007 Nov. PMID 17714440
  3. Subcellular localization of Arabidopsis 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Leivar P, et al. Plant Physiol, 2005 Jan. PMID 15618432, Free PMC Article
  4. Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. Suzuki M, et al. Plant J, 2004 Mar. PMID 14871314
  5. Isolation and structural characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methylglutaryl coenzyme A reductase. Caelles C, et al. Plant Mol Biol, 1989 Dec. PMID 2491679

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that AKIN10 phosphorylates and inactivates HMGR; AKIN10 phosphorylates not only conserved Ser577 in active site but also other site/sites in noncatalytic domain of HMGR; inactivation of HMGR by AKIN10 requires interaction of AKIN10 with GRIK1. (AKIN10 = SnRK1 protein kinase; HMGR = hydroxymethylglutaryl-CoA-reductase; GRIK1 = geminivirus Rep-interacting kinase 1)
    Title: AKIN10, a representative Arabidopsis SNF1-related protein kinase 1 (SnRK1), phosphorylates and downregulates plant HMG-CoA reductase.
  2. The membrane domain of HMGR contributes to endoplasmic reticulum morphogenesis in plant cells.
    Title: Proliferation and Morphogenesis of the Endoplasmic Reticulum Driven by the Membrane Domain of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Plant Cells.
  3. PP2A exerts multilevel control on HMGR through the five-member B'' protein family during normal development and in response to a variety of stress conditions.
    Title: Multilevel control of Arabidopsis 3-hydroxy-3-methylglutaryl coenzyme A reductase by protein phosphatase 2A.
  4. HMG1 or HMG2 is required for male gametophyte development.
    Title: Complete blockage of the mevalonate pathway results in male gametophyte lethality.
  5. increases essential oil yield in spike lavender
    Title: Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia.
  6. Subcellular localization of the expression of the gene in A. thaliana.
    Title: Subcellular localization of Arabidopsis 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_106299.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in coenzyme A metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, mevalonate pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within isoprenoid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within isoprenoid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within sterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
NOT located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in plastid IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hydroxy methylglutaryl CoA reductase 1
NP_177775.2
  • hydroxy methylglutaryl CoA reductase 1 (HMG1); CONTAINS InterPro DOMAIN/s: Hydroxymethylglutaryl-CoA reductase, class I, catalytic (InterPro:IPR004554), Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding (InterPro:IPR009029), Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding (InterPro:IPR009023), Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic (InterPro:IPR002202); BEST Arabidopsis thaliana protein match is: 3-hydroxy-3-methylglutaryl-CoA reductase 2 (TAIR:AT2G17370.1); Has 2212 Blast hits to 2210 proteins in 935 species: Archae - 202; Bacteria - 1018; Metazoa - 225; Fungi - 225; Plants - 266; Viruses - 1; Other Eukaryotes - 275 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    28695760..28698852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_106299.4 → NP_177775.2  hydroxy methylglutaryl CoA reductase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_177775.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P14891, Q6RW12
    UniProtKB/TrEMBL
    A0A178W3L3, A0A5S9WUZ6, A0A654ER34
    Conserved Domains (1) summary
    cd00643
    Location:223 → 626
    HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
Nucleotide Protein
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