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IMPA-4 importin alpha isoform 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837448, updated on 15-Oct-2023

Summary

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Gene symbol
IMPA-4
Gene description
importin alpha isoform 4
Primary source
Araport:AT1G09270
Locus tag
AT1G09270
See related
TAIR:AT1G09270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
importin alpha isoform 4; T12M4.2; T12M4_2
Summary
Protein interacts with Agrobacterium proteins VirD2 and VirE2.
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Genomic context

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See IMPA-4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Sequence:
Chromosome: 1; NC_003070.9 (2994331..2998222)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene rhodanese-like domain protein Neighboring gene uncharacterized protein Neighboring gene Metallopeptidase M24 family protein Neighboring gene plant/protein (Protein of unknown function, DUF538) Neighboring gene agenet domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. IMPa-4, an Arabidopsis importin alpha isoform, is preferentially involved in agrobacterium-mediated plant transformation. Bhattacharjee S, et al. Plant Cell, 2008 Oct. PMID 18836040, Free PMC Article
  2. Telomerase Interaction Partners-Insight from Plants. Fulnečková J, et al. Int J Mol Sci, 2021 Dec 29. PMID 35008793, Free PMC Article
  3. Tandem affinity purification of AtTERT reveals putative interaction partners of plant telomerase in vivo. Majerská J, et al. Protoplasma, 2017 Jul. PMID 27853871
  4. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article
  5. Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. Tamura K, et al. Plant Cell, 2010 Dec. PMID 21189294, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of the importin IMPa-4 inhibits Agrobacterium mediated transformation.
    Title: IMPa-4, an Arabidopsis importin alpha isoform, is preferentially involved in agrobacterium-mediated plant transformation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001035934.2
NM_100797.6
NM_179292.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within host response to induction by symbiont of tumor, nodule or growth in host IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within symbiont intracellular protein transport in host IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
importin alpha isoform 4
NP_001031011.1
  • importin alpha isoform 4 (IMPA-4); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, symbiont intracellular protein transport in host, host response to induction by symbiont of tumor, nodule or growth in host; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 1 (TAIR:AT3G06720.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_172398.1
  • importin alpha isoform 4 (IMPA-4); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, symbiont intracellular protein transport in host, host response to induction by symbiont of tumor, nodule or growth in host; LOCATED IN: nucleus, nuclear pore, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 1 (TAIR:AT3G06720.2); Has 4272 Blast hits to 3104 proteins in 282 species: Archae - 2; Bacteria - 6; Metazoa - 1653; Fungi - 615; Plants - 1226; Viruses - 0; Other Eukaryotes - 770 (source: NCBI BLink).
NP_849623.1
  • importin alpha isoform 4 (IMPA-4); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, symbiont intracellular protein transport in host, host response to induction by symbiont of tumor, nodule or growth in host; LOCATED IN: nucleus, nuclear pore, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 1 (TAIR:AT3G06720.2); Has 4272 Blast hits to 3104 proteins in 282 species: Archae - 2; Bacteria - 6; Metazoa - 1653; Fungi - 615; Plants - 1226; Viruses - 0; Other Eukaryotes - 770 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    2994331..2998222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100797.6 → NP_172398.1  importin alpha isoform 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172398.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4HZG6, O49602, O80480, Q94KD4
    UniProtKB/TrEMBL
    A0A178WMY7, A0A5S9TEM2
    Conserved Domains (2) summary
    COG5064
    Location:17 → 536
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:118 → 150
    ARM; armadillo repeat [structural motif]

  2. NM_179292.3 → NP_849623.1  importin alpha isoform 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849623.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4HZG6, O49602, O80480, Q94KD4
    UniProtKB/TrEMBL
    A0A178WMY7, A0A5S9TEM2
    Conserved Domains (2) summary
    COG5064
    Location:17 → 536
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:118 → 150
    ARM; armadillo repeat [structural motif]

  3. NM_001035934.2 → NP_001031011.1  importin alpha isoform 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031011.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9TEM2
    Conserved Domains (4) summary
    cd00020
    Location:34 → 155
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:2 → 19
    IBB; Importin beta binding domain
    pfam13646
    Location:42 → 151
    HEAT_2; HEAT repeats
    sd00043
    Location:36 → 68
    ARM; armadillo repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O80480.1

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