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I-2 phosphoprotein phosphatase inhibitor [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835296, updated on 7-Sep-2023

Summary

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Gene symbol
I-2
Gene description
phosphoprotein phosphatase inhibitor
Primary source
Araport:AT5G52200
Locus tag
AT5G52200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtI-2; F17P19.10; F17P19_10; inhibitor-2
Summary
Encodes an inhibitor of protein phosphatase one (PP1).
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Genomic context

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Location:
chromosome: 5
Exon count:
4
Sequence:
Chromosome: 5; NC_003076.8 (21202549..21204816, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene homeodomain GLABROUS 7 Neighboring gene transmembrane protein 161AB protein Neighboring gene Sugar isomerase (SIS) family protein Neighboring gene GTP-binding protein 1 Neighboring gene ncRNA Neighboring gene chromosome transmission fidelity-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling. Hou YJ, et al. PLoS Genet, 2016 Mar. PMID 26943172, Free PMC Article
  2. Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit. Templeton GW, et al. Biochem J, 2011 Apr 1. PMID 21222654
  3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
  4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TOPP1 and AtI-2 are negative regulators of ABA signaling.
    Title: Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling.
  2. AtI-2 inhibits the phosphatase activity of all PP1 isoforms of Arabidopsis. [AtI-2]
    Title: Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001344988.1
NM_124599.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plastid HDA PubMed 

General protein information

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Preferred Names
phosphoprotein phosphatase inhibitor
NP_001318787.1
  • phosphoprotein phosphatase inhibitors; FUNCTIONS IN: phosphoprotein phosphatase inhibitor activity; INVOLVED IN: regulation of signal transduction, regulation of phosphoprotein phosphatase activity; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein phosphatase inhibitor 2 (IPP-2) (InterPro:IPR007062).
NP_568768.1
  • phosphoprotein phosphatase inhibitors; FUNCTIONS IN: phosphoprotein phosphatase inhibitor activity; INVOLVED IN: regulation of signal transduction, regulation of phosphoprotein phosphatase activity; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein phosphatase inhibitor 2 (IPP-2) (InterPro:IPR007062); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    21202549..21204816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001344989.1 → NP_001332547.1  phosphoprotein phosphatase inhibitor [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4KEU1

  2. NM_001344988.1 → NP_001318787.1  phosphoprotein phosphatase inhibitor [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4KEU1

  3. NM_124599.5 → NP_568768.1  phosphoprotein phosphatase inhibitor [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568768.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LTK0
    UniProtKB/TrEMBL
    A0A178UH99, A0A5S9YD95
    Conserved Domains (1) summary
    pfam04979
    Location:9 → 141
    IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LTK0.1

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