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GNL1 GNOM-like 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 833946, updated on 15-Oct-2023

Summary

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Gene symbol
GNL1
Gene description
GNOM-like 1
Primary source
Araport:AT5G39500
Locus tag
AT5G39500
See related
TAIR:AT5G39500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ENDOPLASMIC RETICULUM MORPHOLOGY 1; ERMO1; GNOM-like 1; MUL8.180; MUL8_180
Summary
Encodes GNOM-LIKE1/ERMO1, a member of ARF-GEF family. Required for endoplasmic reticulum (ER) morphology.
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Genomic context

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See GNL1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_003076.8 (15814559..15820151)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Plant self-incompatibility protein S1 family Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene Vesicle transport v-SNARE family protein Neighboring gene hypothetical protein (DUF1997)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The integrity of the plant Golgi apparatus depends on cell growth-controlled activity of GNL1. Du W, et al. Mol Plant, 2013 May. PMID 23125314
  2. An ARF-GEF acting at the Golgi and in selective endocytosis in polarized plant cells. Teh OK, et al. Nature, 2007 Jul 26. PMID 17653191
  3. GNOM-LIKE1/ERMO1 and SEC24a/ERMO2 are required for maintenance of endoplasmic reticulum morphology in Arabidopsis thaliana. Nakano RT, et al. Plant Cell, 2009 Nov. PMID 19933201, Free PMC Article
  4. Functional diversification of closely related ARF-GEFs in protein secretion and recycling. Richter S, et al. Nature, 2007 Jul 26. PMID 17653190
  5. GNOM-LIKE 2, encoding an adenosine diphosphate-ribosylation factor-guanine nucleotide exchange factor protein homologous to GNOM and GNL1, is essential for pollen germination in Arabidopsis. Jia DJ, et al. J Integr Plant Biol, 2009 Aug. PMID 19686373

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data reveal an unanticipated level of complexity in the biology of GNL1 by showing that its cellular roles are correlated with cell growth.
    Title: The integrity of the plant Golgi apparatus depends on cell growth-controlled activity of GNL1.
  2. GNL2 encodes a protein homologous to the adenosine diphosphate-ribosylation factor-guanine nucleotide exchange factors, GNOM and GNL1 that are involved in endosomal recycling and endoplasmic reticulum-Golgi vesicular trafficking
    Title: GNOM-LIKE 2, encoding an adenosine diphosphate-ribosylation factor-guanine nucleotide exchange factor protein homologous to GNOM and GNL1, is essential for pollen germination in Arabidopsis.
  3. GNL1 is a BFA-resistant GBF protein that functions with a BFA-sensitive ARF-GEF both at the Golgi and in selective endocytosis, but not in recycling from endosomes. [GNL1]
    Title: An ARF-GEF acting at the Golgi and in selective endocytosis in polarized plant cells.
  4. Large ARF-GEFs of the GBF1 class perform a conserved role in endoplasmic reticulum-Golgi trafficking and secretion, which is done by GNL1 and GNOM in Arabidopsis. [GNL1]
    Title: Functional diversification of closely related ARF-GEFs in protein secretion and recycling.
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General gene information

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Homology

NM_001344295.1
NM_123312.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ER body organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GNOM-like 1
NP_001318705.1
  • GNOM-like 1 (GNL1); FUNCTIONS IN: ARF guanyl-nucleotide exchange factor activity; INVOLVED IN: ER body organization; LOCATED IN: intracellular; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: SEC7-like (InterPro:IPR000904); BEST Arabidopsis thaliana protein match is: sec7 domain-containing protein (TAIR:AT1G13980.2); Has 2885 Blast hits to 2457 proteins in 243 species: Archae - 0; Bacteria - 32; Metazoa - 1491; Fungi - 682; Plants - 262; Viruses - 0; Other Eukaryotes - 418 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    15814559..15820151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001344295.1 → NP_001318705.1  GNOM-like 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FLY5
    UniProtKB/TrEMBL
    A0A178UGI4, A0A5S9Y9Q8, A0A654G6L0
    Conserved Domains (1) summary
    PLN03076
    Location:352 → 1295
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

  2. NM_123312.2 → NP_198766.1  GNOM-like 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_198766.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FLY5
    UniProtKB/TrEMBL
    A0A178UGI4, A0A5S9Y9Q8, A0A654G6L0
    Conserved Domains (1) summary
    PLN03076
    Location:352 → 1295
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FLY5.1

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