CAM1 calmodulin 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CAM1
Official Full Name: calmodulin 1
Primary source: TAIR:AT5G37780
Locus tag: AT5G37780
See related: Araport:AT5G37780
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACAM-1; calmodulin 1; K22F20.20; K22F20_20; TCH1; TOUCH 1
Summary: encodes a calmodulin that is involved in thigmomorphogenesis. Gene expression is rapidly induced upon a variety of abiotic stimuli, including water spray, subirrigation, wind, touch, wounding, or darkness.
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Genomic context

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Location:: chromosome: 5

Exon count:: 4

Sequence:: Chromosome: 5; NC_003076.8 (15004466..15006267, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rapid kinetics of calcium dissociation from plant calmodulin and calmodulin-like proteins and effect of target peptides.
Title: Rapid kinetics of calcium dissociation from plant calmodulin and calmodulin-like proteins and effect of target peptides.
Ca(2+) and CaM are strictly necessary for protein import and normal functionality of peroxisomal enzymes, including antioxidant and photorespiratory enzymes, as well as for nitric oxide production.
Title: Calmodulin antagonist affects peroxisomal functionality by disrupting both peroxisomal Ca(2+) and protein import.
Here, the authors determined crystal structures of AtBAG5 alone and in complex with Ca(2+)-free CaM. Structural and biochemical studies revealed that Ca(2+)-free CaM and Hsc70 bind AtBAG5 independently, whereas Ca(2+)-saturated CaM and Hsc70 bind AtBAG5 with negative cooperativity.
Title: CaM/BAG5/Hsc70 signaling complex dynamically regulates leaf senescence.
mutations in the two lobes affect GAD1 activation in similar ways and only intact AtCaM1 can fully activate GAD1. Taken together, our data provide new insights into the CaM lobes role in interactions between CaM and plant GAD.
Title: Biochemical and biophysical characterization of a plant calmodulin: Role of the N- and C-lobes in calcium binding, conformational change, and target interaction.
the PPIase activity of the Arabidopsis cyclophilin was not affected by CaM
Title: Characterization of Peptidyl-Prolyl Cis-Trans Isomerase- and Calmodulin-Binding Activity of a Cytosolic Arabidopsis thaliana Cyclophilin AtCyp19-3.
Ca(2+)/Calmodulin-mediated signaling regulates plant response to herbivore attack/wounding by modulating the salicylic acid-jasmonic acid crosstalk through AtSR1.
Title: Coupling calcium/calmodulin-mediated signaling and herbivore-induced plant response through calmodulin-binding transcription factor AtSR1/CAMTA3.
Data show that the level of CAM1 and CAM5 gene mRNAs were consistently greater in response to heat stress in both root and shoot.
Title: Expression of calmodulin genes in wild type and calmodulin mutants of Arabidopsis thaliana under heat stress.
the cytosolic face of ACA8 mediates early CaM recognition and CaM subsequently competes with the intramolecular autoinhibitor in binding to the other face of the helix
Title: The plant plasma membrane Ca2+ pump ACA8 contains overlapping as well as physically separated autoinhibitory and calmodulin-binding domains.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001161282.1

Supported by ESTs:

NM_001161283.1

Supported by ESTs:

NM_001344219.1

Supported by ESTs:

NM_123137.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	NAS Non-traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within detection of calcium ion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: calmodulin 1

NP_001154754.1

calmodulin 1 (CAM1); CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 4 (TAIR:AT1G66410.1); Has 30779 Blast hits to 22253 proteins in 1727 species: Archae - 2; Bacteria - 134; Metazoa - 13527; Fungi - 6643; Plants - 6315; Viruses - 0; Other Eukaryotes - 4158 (source: NCBI BLink).

NP_001154755.1

calmodulin 1 (CAM1); CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 4 (TAIR:AT1G66410.1); Has 29914 Blast hits to 22079 proteins in 1723 species: Archae - 3; Bacteria - 127; Metazoa - 13080; Fungi - 6590; Plants - 6083; Viruses - 0; Other Eukaryotes - 4031 (source: NCBI BLink).

NP_198594.1

calmodulin 1 (CAM1); FUNCTIONS IN: calcium ion binding; INVOLVED IN: detection of calcium ion, response to mechanical stimulus; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 4 (TAIR:AT1G66410.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

15004466..15006267 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123137.4 → NP_198594.1 calmodulin 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_198594.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P0DH95, P0DH96, P25854, Q03510, Q9FJ05

UniProtKB/TrEMBL

A0A178WBP5, A0A5S9WQ45, A8Y7S8

Conserved Domains (1) summary

PTZ00184
Location:1 → 149

PTZ00184; calmodulin; Provisional
NM_001161283.1 → NP_001154755.1 calmodulin 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001154755.1

Status: REVIEWED

UniProtKB/TrEMBL

A8Y7S8, F4K8M2

Conserved Domains (2) summary

PTZ00184
Location:1 → 175

PTZ00184; calmodulin; Provisional

cd00051
Location:111 → 173

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001161282.1 → NP_001154754.1 calmodulin 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001154754.1

Status: REVIEWED

UniProtKB/TrEMBL

A8Y7S8, F4K8M3

Conserved Domains (2) summary

PTZ00184
Location:1 → 164

PTZ00184; calmodulin; Provisional

cd00051
Location:100 → 162

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001344219.1 → NP_001330399.1 calmodulin 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BAP4, A8Y7S8