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ADK2 adenosine kinase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831882, updated on 18-Sep-2024

Summary

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Official Symbol
ADK2
Official Full Name
adenosine kinase 2
Primary source
TAIR:AT5G03300
Locus tag
AT5G03300
See related
Araport:AT5G03300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
adenosine kinase 2; ADENOSINE KINASE 2; F12E4.30; F12E4_30
Summary
Encodes adenosine kinase 2 (ADK2), a typical, constitutively expressed housekeeping enzyme. Shows a high sequence identity with ADK1. Involved in salvage synthesis of adenylates and methyl recycling. Enzyme activity is substantially inhibited in roots, siliques and dry seeds by an unknown compound. May contribute to cytokinin interconversion.
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Genomic context

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See ADK2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
11
Sequence:
Chromosome: 5; NC_003076.8 (796361..799810)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene isocitrate dehydrogenase V Neighboring gene SAUR-like auxin-responsive protein family Neighboring gene ncRNA Neighboring gene Protein kinase superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Adenosine kinase of Arabidopsis. Kinetic properties and gene expression. Moffatt BA, et al. Plant Physiol, 2000 Dec. PMID 11115893, Free PMC Article
  2. A complex containing SNF1-related kinase (SnRK1) and adenosine kinase in Arabidopsis. Mohannath G, et al. PLoS One, 2014. PMID 24498147, Free PMC Article
  3. Proteomic survey of copper-binding proteins in Arabidopsis roots by immobilized metal affinity chromatography and mass spectrometry. Kung CC, et al. Proteomics, 2006 May. PMID 16526091
  4. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812
  5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_120408.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables adenosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables copper ion binding HDA PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in AMP salvage IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within adenosine salvage TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
adenosine kinase 2
NP_195950.1
  • adenosine kinase 2 (ADK2); FUNCTIONS IN: adenosine kinase activity, copper ion binding, kinase activity; INVOLVED IN: adenosine salvage; LOCATED IN: plasma membrane; EXPRESSED IN: 33 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Carbohydrate/purine kinase (InterPro:IPR011611), Carbohydrate/puine kinase, PfkB, conserved site (InterPro:IPR002173), Adenosine kinase (InterPro:IPR001805); BEST Arabidopsis thaliana protein match is: adenosine kinase 1 (TAIR:AT3G09820.1); Has 9730 Blast hits to 9724 proteins in 1887 species: Archae - 143; Bacteria - 5874; Metazoa - 382; Fungi - 207; Plants - 398; Viruses - 0; Other Eukaryotes - 2726 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    796361..799810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001342696.1 → NP_001330384.1  adenosine kinase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UGH7, A0A1P8BAP0

  2. NM_001342697.1 → NP_001330385.1  adenosine kinase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UGH7, A0A1P8BAP0

  3. NM_120408.4 → NP_195950.1  adenosine kinase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195950.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LZG0
    UniProtKB/TrEMBL
    A0A178UGH7
    Conserved Domains (1) summary
    PLN02548
    Location:14 → 345
    PLN02548; adenosine kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LZG0.1

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