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ATSTE14B Isoprenylcysteine carboxyl methyltransferase (ICMT) family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830731, updated on 7-Sep-2023

Summary

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Gene symbol
ATSTE14B
Gene description
Isoprenylcysteine carboxyl methyltransferase (ICMT) family
Primary source
Araport:AT5G08335
Locus tag
AT5G08335
See related
TAIR:AT5G08335
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA ISOPRENYL CYSTEINE METHYLTRANSFERASE B; ATICMTB; ICMTB; ISOPRENYL CYSTEINE METHYLTRANSFERASE B
Summary
Encodes an isoprenyl cysteine methylatransferase (ICMT) involved in the post-translational processing of proteins that have a C-terminal CaaX box. This protein appears to have higher catalytic activity and a higher transcript expression level than the other ICMT present in Arabidopsis (At5g23320). Analysis of ICMT RNAi lines suggests that this protein is involved in flower and stem development.
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Genomic context

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See ATSTE14B in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_003076.8 (2681996..2683780)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene E2F-associated phosphoprotein Neighboring gene TCP family transcription factor Neighboring gene Nucleotidylyl transferase superfamily protein Neighboring gene GRAM domain-containing protein / ABA-responsive protein-like protein Neighboring gene Stu1, putative (DUF789) Neighboring gene alpha-galactosidase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prenylcysteine alpha-carboxyl methyltransferase expression and function in Arabidopsis thaliana. Narasimha Chary S, et al. Plant J, 2002 Dec. PMID 12472689
  2. Functional analysis of Arabidopsis postprenylation CaaX processing enzymes and their function in subcellular protein targeting. Bracha-Drori K, et al. Plant Physiol, 2008 Sep. PMID 18641086, Free PMC Article
  3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. major isoprenyl cysteine methyltransferase that modulates activity of prenylated proteins
    Title: Functional analysis of Arabidopsis postprenylation CaaX processing enzymes and their function in subcellular protein targeting.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001342996.1
NM_120917.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within flower development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of abscisic acid-activated signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within shoot system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Isoprenylcysteine carboxyl methyltransferase (ICMT) family
NP_568191.1
  • ATSTE14B; CONTAINS InterPro DOMAIN/s: Isoprenylcysteine carboxyl methyltransferase (InterPro:IPR007269); BEST Arabidopsis thaliana protein match is: homolog of yeast STE14 A (TAIR:AT5G23320.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    2681996..2683780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120917.2 → NP_568191.1  Isoprenylcysteine carboxyl methyltransferase (ICMT) family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568191.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93W54, Q9FTA1
    UniProtKB/TrEMBL
    A0A178UID5, A0A5S9Y2G9, A0A654FZI6
    Conserved Domains (1) summary
    COG2020
    Location:16 → 196
    STE14; Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones]

  2. NM_001342996.1 → NP_001331317.1  Isoprenylcysteine carboxyl methyltransferase (ICMT) family [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93W54, Q9FTA1
    UniProtKB/TrEMBL
    A0A178UID5, A0A5S9Y2G9, A0A654FZI6
    Conserved Domains (1) summary
    COG2020
    Location:16 → 196
    STE14; Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q93W54.1

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