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ATH1 homeobox protein ATH1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829435, updated on 18-Sep-2024

Summary

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Official Symbol
ATH1
Official Full Name
homeobox protein ATH1
Primary source
TAIR:AT4G32980
Locus tag
AT4G32980
See related
Araport:AT4G32980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F26P21.100; F26P21_100; homeobox gene 1
Summary
Encodes transcription factor involved in photomorphogenesis. Regulates gibberellin biosynthesis. Activated by AGAMOUS in a cal-1, ap1-1 background. Expressed at low levels in developing stamens. Increased levels of ATH1 severely delay flowering in the C24 accession. Most remarkably, ectopically expressed ATH1 hardly had an effect on flowering time in the Col-0 and Ler accessions. ATH1 physically interacts with STM, BP and KNAT6 and enhances the shoot apical meristem defect of some of these genes suggesting a role in SAM maintenance. Nuclear localization is dependent upon interaction with STM.
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Genomic context

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See ATH1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
6
Sequence:
Chromosome: 4; NC_003075.7 (15914670..15918153, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene BRISC/BRCA1-A complex protein Neighboring gene BRISC/BRCA1-A complex protein Neighboring gene ncRNA Neighboring gene Transducin/WD40 repeat-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis thaliana rosette habit is controlled by combined light and energy signaling converging on transcriptional control of the TALE homeobox gene ATH1. Shokrian Hajibehzad S, et al. New Phytol, 2023 Aug. PMID 37291904
  2. ARABIDOPSIS THALIANA HOMEOBOX GENE 1 controls plant architecture by locally restricting environmental responses. Ejaz M, et al. Proc Natl Acad Sci U S A, 2021 Apr 27. PMID 33888582, Free PMC Article
  3. ARABIDOPSIS THALIANA HOMEOBOX GENE1 establishes the basal boundaries of shoot organs and controls stem growth. Gómez-Mena C, et al. Plant Cell, 2008 Aug. PMID 18757555, Free PMC Article
  4. Interaction of the BELL-like protein ATH1 with DNA: role of homeodomain residue 54 in specifying the different binding properties of BELL and KNOX proteins. Viola IL, et al. Biol Chem, 2006 Jan. PMID 16497162
  5. Light Regulation of Gibberellin Biosynthesis and Mode of Action. García-Martinez JL, et al. J Plant Growth Regul, 2001 Dec. PMID 11986761

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis thaliana rosette habit is controlled by combined light and energy signaling converging on transcriptional control of the TALE homeobox gene ATH1.
    Title: Arabidopsis thaliana rosette habit is controlled by combined light and energy signaling converging on transcriptional control of the TALE homeobox gene ATH1.
  2. BOP1/2 gain-of-function in stems promotes expression of the boundary gene KNOTTED1-LIKE FROM ARABIDOPSIS THALIANA6 (KNAT6) and ARABIDOPSIS THALIANA HOMEOBOX GENE1 (ATH1).
    Title: BLADE-ON-PETIOLE1 and 2 regulate Arabidopsis inflorescence architecture in conjunction with homeobox genes KNAT6 and ATH1.
  3. The data indicate that the ATH1-KNAT2 complex acts redundantly with KNAT6, both of which are negatively regulated by BP during pedicel development.
    Title: ATH1 and KNAT2 proteins act together in regulation of plant inflorescence architecture.
  4. combined lesions in ATH1, PNY and PNF result in a full phenocopy of shoot apical meristem loss-of-function mutants.
    Title: Shoot apical meristem function in Arabidopsis requires the combined activities of three BEL1-like homeodomain proteins.
  5. Data show that ATH1 modulates growth at the interface between the stem, meristem, and organ primordia and contributes to the compressed vegetative habit of Arabidopsis thaliana.
    Title: ARABIDOPSIS THALIANA HOMEOBOX GENE1 establishes the basal boundaries of shoot organs and controls stem growth.
  6. ATH1 controls floral competency as a specific activator of FLOWERING LOCUS C (FLC) expression.
    Title: The Arabidopsis TALE homeobox gene ATH1 controls floral competency through positive regulation of FLC.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001342189.1
NM_119452.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within floral organ abscission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meristem maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photomorphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of gibberellin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within shoot organ boundary specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
homeobox protein ATH1
NP_195024.1
  • homeobox gene 1 (ATH1); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), POX (InterPro:IPR006563), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: BEL1-like homeodomain 7 (TAIR:AT2G16400.1); Has 5042 Blast hits to 5042 proteins in 335 species: Archae - 0; Bacteria - 0; Metazoa - 2114; Fungi - 285; Plants - 2468; Viruses - 0; Other Eukaryotes - 175 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    15914670..15918153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119452.4 → NP_195024.1  homeobox protein ATH1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195024.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48731, Q7X9S7
    UniProtKB/TrEMBL
    A0A178V1Z5, A0A654FVB6
    Conserved Domains (2) summary
    smart00574
    Location:196 → 334
    POX; domain associated with HOX domains
    pfam05920
    Location:390 → 429
    Homeobox_KN; Homeobox KN domain

  2. NM_001342189.1 → NP_001328067.1  homeobox protein ATH1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48731, Q7X9S7
    UniProtKB/TrEMBL
    A0A178V1Z5, A0A654FVB6
    Conserved Domains (2) summary
    smart00574
    Location:196 → 334
    POX; domain associated with HOX domains
    pfam05920
    Location:390 → 429
    Homeobox_KN; Homeobox KN domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48731.1

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