PHO1 phosphate 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: PHO1
Gene description: phosphate 1
Primary source: Araport:AT3G23430
Locus tag: AT3G23430
See related: TAIR:AT3G23430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS PHOSPHATE 1; ATPHO1; phosphate 1
Summary: mutant is deficient in the transfer of phosphate from root epidermal and cortical cells to the xylem. encodes protein with the mainly hydrophilic N-terminal and the C-terminal containing 6 potential membrane-spanning domains.
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Genomic context

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See PHO1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 15

Sequence:: Chromosome: 3; NC_003074.8 (8387398..8393467, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Arabidopsis PHOSPHATE 1 exporter undergoes constitutive internalization via clathrin-mediated endocytosis.
Title: The Arabidopsis PHOSPHATE 1 exporter undergoes constitutive internalization via clathrin-mediated endocytosis.
Modulation of Shoot Phosphate Level and Growth by PHOSPHATE1 Upstream Open Reading Frame.
Title: Modulation of Shoot Phosphate Level and Growth by PHOSPHATE1 Upstream Open Reading Frame.
These data demonstrate that PHO1 is involved in ABA-mediated seed germination and early seedling development and transcriptionally regulated by ABI5.
Title: Abscisic Acid Modulates Seed Germination via ABA INSENSITIVE5-Mediated PHOSPHATE1.
The Arabidopsis Pi exporters PHO1 and PHOH1 are expressed in the chalazal seed coat (CZSC) of developing seeds. PHO1 is additionally expressed in developing ovules. Phosphorus (P) content and Pi flux between the seed coat and embryo were analyzed in seeds from grafts between WT roots and scions from either pho1, phoh1, or the pho1 phoh1 double mutant.
Title: PHO1 Exports Phosphate from the Chalazal Seed Coat to the Embryo in Developing Arabidopsis Seeds.
An important role of the EXS domain of PHO1 in a root-to-shoot signaling pathway linking phosphate deficiency response
Title: The EXS Domain of PHO1 Participates in the Response of Shoots to Phosphate Deficiency via a Root-to-Shoot Signal.
AtWRKY42 modulated Pi homeostasis by regulating the expression of PHO1 and PHT1;1 to adapt to environmental changes in inorganic phosphate (Pi) availability.
Title: WRKY42 modulates phosphate homeostasis through regulating phosphate translocation and acquisition in Arabidopsis.
PHR1 and PHO1 participate in the coregulation of Zn and Pi homeostasis.
Title: Coordination between zinc and phosphate homeostasis involves the transcription factor PHR1, the phosphate exporter PHO1, and its homologue PHO1;H3 in Arabidopsis.
Genome-wide association mapping identified PHOSPHATE 1 (PHO1) and genes such as Root System Architecture 1 (RSA1) associated with differences in root allometry, a highly plastic trait capturing the distribution of lateral roots along the primary axis.
Title: Integration of responses within and across Arabidopsis natural accessions uncovers loci controlling root systems architecture.
Expression of PHO1 in guard cells of Arabidopsis thaliana is required for full stomatal responses to abscisic acid.
Title: PHO1 expression in guard cells mediates the stomatal response to abscisic acid in Arabidopsis.
PHO1 can trigger Pi export in ectopic plant cells, strongly indicating that PHO1 is itself a Pi exporter.
Title: Functional expression of PHO1 to the Golgi and trans-Golgi network and its role in export of inorganic phosphate.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

At-9GBJ-076 (e-PCR)
- UniSTS:229459

Homology

Orthologs from OrthoDB

NM_113246.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables inositol hexakisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to phosphate starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular phosphate ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphate ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polyphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular anatomical structure	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphate 1

NP_188985.2

phosphate 1 (PHO1); INVOLVED IN: cellular response to phosphate starvation, phosphate transport; LOCATED IN: integral to membrane; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: EXS, C-terminal (InterPro:IPR004342), SPX, N-terminal (InterPro:IPR004331); BEST Arabidopsis thaliana protein match is: EXS (ERD1/XPR1/SYG1) family protein (TAIR:AT1G68740.1); Has 1217 Blast hits to 1145 proteins in 207 species: Archae - 2; Bacteria - 0; Metazoa - 255; Fungi - 408; Plants - 406; Viruses - 0; Other Eukaryotes - 146 (source: NCBI BLink).