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RAD23C Rad23 UV excision repair protein family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821195, updated on 18-Sep-2024

Summary

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Official Symbol
RAD23C
Official Full Name
Rad23 UV excision repair protein family
Primary source
TAIR:AT3G02540
Locus tag
AT3G02540
See related
Araport:AT3G02540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F16B3.17; F16B3_17; PUTATIVE DNA REPAIR PROTEIN RAD23-3; RAD23-3; RADIATION SENSITIVE23C
Summary
Encodes a member of the RADIATION SENSITIVE23 (RAD23) family: AT1G16190(RAD23A), AT1G79650(RAD23B), AT3G02540(RAD23C), AT5G38470(RAD23D). RAD23 proteins play an essential role in the cell cycle, morphology, and fertility of plants through their delivery of UPS (ubiquitin/26S proteasome system) substrates to the 26S proteasome.
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Genomic context

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Location:
chromosome: 3
Exon count:
12
Sequence:
Chromosome: 3; NC_003074.8 (532808..536414, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene general regulatory factor 7 Neighboring gene TCP-1/cpn60 chaperonin family protein Neighboring gene LOB domain-containing protein 41 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The RAD23 family provides an essential connection between the 26S proteasome and ubiquitylated proteins in Arabidopsis. Farmer LM, et al. Plant Cell, 2010 Jan. PMID 20086187, Free PMC Article
  2. The defective proteasome but not substrate recognition function is responsible for the null phenotypes of the Arabidopsis proteasome subunit RPN10. Lin YL, et al. Plant Cell, 2011 Jul. PMID 21764993, Free PMC Article
  3. Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis. Fatimababy AS, et al. FEBS J, 2010 Feb. PMID 20059542
  4. Telomerase Interaction Partners-Insight from Plants. Fulnečková J, et al. Int J Mol Sci, 2021 Dec 29. PMID 35008793, Free PMC Article
  5. Tandem affinity purification of AtTERT reveals putative interaction partners of plant telomerase in vivo. Majerská J, et al. Protoplasma, 2017 Jul. PMID 27853871

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001202864.1
NM_202482.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables proteasome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in UV protection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within_positive_effect response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Rad23 UV excision repair protein family
NP_001189793.1
  • RADIATION SENSITIVE23C (RAD23C); FUNCTIONS IN: ubiquitin binding, proteasome binding; INVOLVED IN: proteasomal ubiquitin-dependent protein catabolic process, nucleotide-excision repair; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Heat shock chaperonin-binding (InterPro:IPR006636), Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), UV excision repair protein Rad23 (InterPro:IPR004806), Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955), XPC-binding domain (InterPro:IPR015360), UBA-like (InterPro:IPR009060); BEST Arabidopsis thaliana protein match is: Rad23 UV excision repair protein family (TAIR:AT5G38470.1).
NP_186903.1
  • RADIATION SENSITIVE23C (RAD23C); FUNCTIONS IN: ubiquitin binding, proteasome binding; INVOLVED IN: proteasomal ubiquitin-dependent protein catabolic process, nucleotide-excision repair; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Heat shock chaperonin-binding (InterPro:IPR006636), Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), UV excision repair protein Rad23 (InterPro:IPR004806), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Ubiquitin (InterPro:IPR000626), XPC-binding domain (InterPro:IPR015360), Ubiquitin supergroup (InterPro:IPR019955), UBA-like (InterPro:IPR009060); BEST Arabidopsis thaliana protein match is: Rad23 UV excision repair protein family (TAIR:AT5G38470.1); Has 42093 Blast hits to 23907 proteins in 1708 species: Archae - 163; Bacteria - 9780; Metazoa - 10471; Fungi - 4857; Plants - 6883; Viruses - 1548; Other Eukaryotes - 8391 (source: NCBI BLink).
NP_974211.1
  • RADIATION SENSITIVE23C (RAD23C); CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955), UBA-like (InterPro:IPR009060); BEST Arabidopsis thaliana protein match is: Rad23 UV excision repair protein family (TAIR:AT5G38470.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    532808..536414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111121.4 → NP_186903.1  Rad23 UV excision repair protein family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_186903.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q84L31, Q9M887
    UniProtKB/TrEMBL
    A0A178V8E8, A0A5S9X8H5, A0A654F3G6
    Conserved Domains (1) summary
    TIGR00601
    Location:1 → 416
    rad23; UV excision repair protein Rad23

  2. NM_001202864.1 → NP_001189793.1  Rad23 UV excision repair protein family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001189793.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178V8E8, A0A5S9X8H5, F4JD57
    Conserved Domains (6) summary
    cd01805
    Location:1 → 78
    RAD23_N; Ubiquitin-like domain of RAD23
    cd14379
    Location:180 → 229
    UBA1_Rad23_plant; UBA1 domain of putative DNA repair proteins Rad23 found in plant
    cd14382
    Location:370 → 412
    UBA2_RAD23_plant; UBA2 domain of putative DNA repair proteins RAD23 found in plant
    TIGR00601
    Location:1 → 415
    rad23; UV excision repair protein Rad23
    pfam09280
    Location:289 → 344
    XPC-binding; XPC-binding domain
    cl19863
    Location:227 → 319
    DUF935; Protein of unknown function (DUF935)

  3. NM_202482.3 → NP_974211.1  Rad23 UV excision repair protein family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974211.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4JD59
    Conserved Domains (3) summary
    cd01805
    Location:1 → 78
    RAD23_N; Ubiquitin-like domain of RAD23
    smart00213
    Location:1 → 74
    UBQ; Ubiquitin homologues
    cd14379
    Location:181 → 230
    UBA1_Rad23_plant; UBA1 domain of putative DNA repair proteins Rad23 found in plant
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q84L31.2

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