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NEK2 NIMA-related kinase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819641, updated on 15-Feb-2024

Summary

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Gene symbol
NEK2
Gene description
NIMA-related kinase 2
Primary source
Araport:AT3G04810
Locus tag
AT3G04810
See related
TAIR:AT3G04810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATNEK2; NIMA-related kinase 2; NIMA-RELATED KINASE2; T9J14.24; T9J14_24
Summary
Encodes AtNek2, a member of the NIMA-related serine/threonine kinases (Neks) that have been linked to cell-cycle regulation in fungi and mammals. Plant Neks might be involved in plant development processes.
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Genomic context

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See NEK2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
16
Sequence:
Chromosome: 3; NC_003074.8 (1317245..1321294)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Ribose 5-phosphate isomerase, type A protein Neighboring gene ncRNA Neighboring gene translocase inner membrane subunit 23-3 Neighboring gene ncRNA Neighboring gene Pseudouridine synthase family protein Neighboring gene Protein prenylyltransferase superfamily protein Neighboring gene Ribosomal protein S3Ae

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713
  2. Multi-omics network-based functional annotation of unknown Arabidopsis genes. Depuydt T, et al. Plant J, 2021 Nov. PMID 34562334

GeneRIFs: Gene References Into Functions

General gene information

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Homology

NM_001337542.1
NM_111353.4
NM_202492.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
NIMA-related kinase 2
NP_187132.1
  • NIMA-related kinase 2 (NEK2); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: NIMA-related kinase 3 (TAIR:AT5G28290.1); Has 124232 Blast hits to 122078 proteins in 4151 species: Archae - 113; Bacteria - 14232; Metazoa - 45825; Fungi - 12238; Plants - 30614; Viruses - 487; Other Eukaryotes - 20723 (source: NCBI BLink).
NP_974221.2
  • NIMA-related kinase 2 (NEK2); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: NIMA-related kinase 3 (TAIR:AT5G28290.1); Has 124376 Blast hits to 122221 proteins in 4182 species: Archae - 113; Bacteria - 14280; Metazoa - 45892; Fungi - 12262; Plants - 30619; Viruses - 487; Other Eukaryotes - 20723 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    1317245..1321294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_202492.3 → NP_974221.2  NIMA-related kinase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974221.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94K93, Q9CAU7
    UniProtKB/TrEMBL
    A0A178V8L3, A0A5S9X955, A0A654F468, B9DH51, B9DHE1
    Conserved Domains (1) summary
    cd08215
    Location:3 → 258
    STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase

  2. NM_111353.4 → NP_187132.1  NIMA-related kinase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187132.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94K93, Q9CAU7
    UniProtKB/TrEMBL
    A0A178V8L3, A0A5S9X955, A0A654F468, B9DH51, B9DHE1
    Conserved Domains (1) summary
    cd08215
    Location:3 → 258
    STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase

  3. NM_001337542.1 → NP_001327439.1  NIMA-related kinase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94K93, Q9CAU7
    UniProtKB/TrEMBL
    A0A178V8L3, A0A5S9X955, A0A654F468, B9DH51, B9DHE1
    Conserved Domains (1) summary
    cd08215
    Location:3 → 258
    STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CAU7.1

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