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UBP5 ubiquitin-specific protease 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818691, updated on 18-Sep-2024

Summary

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Official Symbol
UBP5
Official Full Name
ubiquitin-specific protease 5
Primary source
TAIR:AT2G40930
Locus tag
AT2G40930
See related
Araport:AT2G40930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATUBP5; PDE323; PIGMENT DEFECTIVE EMBRYO 323; T20B5.13; T20B5_13; ubiquitin-specific protease 5
Summary
Encodes ubiquitin-specific protease with nuclear localization signals that is likely to be involved in ubiquitin-mediated protein degradation.
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Genomic context

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Location:
chromosome: 2
Exon count:
13
Sequence:
Chromosome: 2; NC_003071.7 (17076311..17082528, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene PLAC8 family protein Neighboring gene ethylene response sensor 1 Neighboring gene Basic-leucine zipper (bZIP) transcription factor family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitin-specific proteases from Arabidopsis thaliana: cloning of AtUBP5 and analysis of substrate specificity of AtUBP3, AtUBP4, and AtUBP5 using Escherichia coli in vivo and in vitro assays. Rao-Naik C, et al. Arch Biochem Biophys, 2000 Jul 15. PMID 10898935
  2. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
  3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
  4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBP5 is a new regulator of PRCs activities, directly controlling H2Aub deubiquitination and affecting H3K27 trimethylation to regulate gene expression.
    Title: The UBP5 histone H2A deubiquitinase counteracts PRCs-mediated repression to regulate Arabidopsis development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_129656.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2A deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of gene expression, epigenetic IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin-specific protease 5
NP_565944.1
  • ubiquitin-specific protease 5 (UBP5); CONTAINS InterPro DOMAIN/s: Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site (InterPro:IPR018200), Peptidase C19, ubiquitin-specific peptidase, DUSP domain (InterPro:IPR006615), Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (InterPro:IPR001394); BEST Arabidopsis thaliana protein match is: ubiquitin-specific protease 9 (TAIR:AT4G10570.1); Has 10784 Blast hits to 7330 proteins in 261 species: Archae - 0; Bacteria - 2; Metazoa - 5578; Fungi - 1854; Plants - 1330; Viruses - 10; Other Eukaryotes - 2010 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    17076311..17082528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001336876.1 → NP_001323724.1  ubiquitin-specific protease 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22207, Q9SEX3
    UniProtKB/TrEMBL
    A0A178VRF5, A0A5S9X5Z1, A0A654F614
    Conserved Domains (1) summary
    COG5560
    Location:32 → 917
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

  2. NM_129656.4 → NP_565944.1  ubiquitin-specific protease 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565944.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22207, Q9SEX3
    UniProtKB/TrEMBL
    A0A178VRF5, A0A5S9X5Z1, A0A654F614
    Conserved Domains (1) summary
    COG5560
    Location:32 → 917
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O22207.2

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