PGGT-I Prenyltransferase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: PGGT-I
Gene description: Prenyltransferase family protein
Primary source: Araport:AT2G39550
Locus tag: AT2G39550
See related: TAIR:AT2G39550
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATGGT-IB; GERANYLGERANYLTRANSFERASE-I BETA SUBUNIT; GGB
Summary: encodes the beta subunit of geranylgeranyl transferase (GGT-IB), involved in both ABA-mediated and auxin signaling pathways.
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Genomic context

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See PGGT-I in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 11

Sequence:: Chromosome: 2; NC_003071.7 (16501571..16504379)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PGGT1 exhibits strict specificity for CaaX substrates ending in Leu.
Title: The CaaX specificities of Arabidopsis protein prenyltransferases explain era1 and ggb phenotypes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_129513.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables CAAX-protein geranylgeranyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables CAAX-protein geranylgeranyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of abscisic acid-activated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within protein geranylgeranylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein geranylgeranylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to auxin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CAAX-protein geranylgeranyltransferase complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Prenyltransferase family protein

NP_181487.1

PGGT-I; CONTAINS InterPro DOMAIN/s: Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (InterPro:IPR008930), Prenyltransferase/squalene oxidase (InterPro:IPR001330); BEST Arabidopsis thaliana protein match is: RAB geranylgeranyl transferase beta subunit 1 (TAIR:AT5G12210.1); Has 1518 Blast hits to 1317 proteins in 251 species: Archae - 0; Bacteria - 20; Metazoa - 603; Fungi - 437; Plants - 177; Viruses - 0; Other Eukaryotes - 281 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

16501571..16504379

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129513.4 → NP_181487.1 Prenyltransferase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181487.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O80642, Q9FPP6

UniProtKB/TrEMBL

A0A178VS16, A0A5S9X5G2

Conserved Domains (1) summary

cd02895
Location:37 → 353

GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...