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CYP5 cyclophilin 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817546, updated on 18-Sep-2024

Summary

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Official Symbol
CYP5
Official Full Name
cyclophilin 5
Primary source
TAIR:AT2G29960
Locus tag
AT2G29960
See related
Araport:AT2G29960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA CYCLOPHILIN 5; ATCYP5; CYCLOPHILIN 19-4; cyclophilin 5; CYP19-4; F23F1.12; F23F1_12
Summary
encodes a cyclophilin protein that exhibits peptidylprolyl cis/trans-isomerase and protein refolding activities that were sensitive to cyclosporin A. The protein interacts with GNOM in vitro and is localized to both the cytosolic and membrane fractions. The gene is expressed in the developing embryo.
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Genomic context

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Location:
chromosome: 2
Exon count:
8
Sequence:
Chromosome: 2; NC_003071.7 (12767610..12770668, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene F-box/RNI-like superfamily protein Neighboring gene pleiotropic drug resistance 3 Neighboring gene ELF4-like 1 Neighboring gene ncRNA Neighboring gene Double Clp-N motif-containing P-loop nucleoside triphosphate hydrolases superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved domain of the arabidopsis GNOM protein mediates subunit interaction and cyclophilin 5 binding. Grebe M, et al. Plant Cell, 2000 Mar. PMID 10715321, Free PMC Article
  2. Desensitization of GSTF8 induction by a prior chemical treatment is long lasting and operates in a tissue-dependent manner. Foley RC, et al. Plant Physiol, 2006 Sep. PMID 16829588, Free PMC Article
  3. Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains. Anders N, et al. Plant Cell, 2008 Jan. PMID 18203920, Free PMC Article
  4. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
  5. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001084509.1
NM_001336236.1
NM_128550.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein refolding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in Golgi apparatus RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in multivesicular body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome HDA PubMed 
located_in secretory vesicle HDA PubMed 

General protein information

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Preferred Names
cyclophilin 5
NP_001077978.1
  • cyclophilin 5 (CYP5); FUNCTIONS IN: peptidyl-prolyl cis-trans isomerase activity; INVOLVED IN: protein folding; LOCATED IN: cytosol, Golgi stack, endoplasmic reticulum, membrane fraction, multivesicular body; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (InterPro:IPR020892); BEST Arabidopsis thaliana protein match is: rotamase CYP 7 (TAIR:AT5G58710.1); Has 15750 Blast hits to 15712 proteins in 2648 species: Archae - 109; Bacteria - 6497; Metazoa - 2918; Fungi - 1356; Plants - 1258; Viruses - 4; Other Eukaryotes - 3608 (source: NCBI BLink).
NP_001318316.1
  • cyclophilin 5 (CYP5); FUNCTIONS IN: peptidyl-prolyl cis-trans isomerase activity; INVOLVED IN: protein folding; LOCATED IN: cytosol, Golgi stack, endoplasmic reticulum, membrane fraction, multivesicular body; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (InterPro:IPR020892); BEST Arabidopsis thaliana protein match is: rotamase CYP 7 (TAIR:AT5G58710.1); Has 16420 Blast hits to 16390 proteins in 2652 species: Archae - 108; Bacteria - 6810; Metazoa - 2915; Fungi - 1388; Plants - 1273; Viruses - 4; Other Eukaryotes - 3922 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    12767610..12770668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001336236.1 → NP_001318316.1  cyclophilin 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MS66, O22515, O80876, Q8LDP4
    UniProtKB/TrEMBL
    A0A178VZ96, A0A5S9X2F4, A0A654F2G7
    Conserved Domains (1) summary
    cd01926
    Location:32 → 197
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

  2. NM_128550.4 → NP_180557.1  cyclophilin 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180557.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MS66, O22515, O80876, Q8LDP4
    UniProtKB/TrEMBL
    A0A178VZ96, A0A5S9X2F4, A0A654F2G7
    Conserved Domains (1) summary
    cd01926
    Location:32 → 197
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

  3. NM_001084509.1 → NP_001077978.1  cyclophilin 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001077978.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VZ96
    Conserved Domains (1) summary
    cl00197
    Location:32 → 187
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8LDP4.2

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