ALKBH2 oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: ALKBH2
Gene description: oxidoreductase, 2OG-Fe(II) oxygenase family protein
Primary source: Araport:AT2G22260
Locus tag: AT2G22260
See related: TAIR:AT2G22260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: homolog of E. coli alkB; T26C19.8; T26C19_8
Summary: Encodes a homolog of the E. coli AlkB gene, whose protein product is a DNA repair enzyme important in reversing methylation damage.
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Genomic context

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See ALKBH2 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 8

Sequence:: Chromosome: 2; NC_003071.7 (9460918..9463561)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The present study establishes ALKBH2 as an important enzyme for protecting Arabidopsis against methylation damage in DNA.
Title: The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.

Submit: New GeneRIF Correction

General gene information

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Homology

Orthologs from OrthoDB

NM_001335789.1

Supported by ESTs:

NM_001335790.1

Supported by ESTs:

NM_001335791.1

Supported by ESTs:

NM_001335792.1

Supported by ESTs:

NM_001335793.1

Supported by ESTs:

NM_127792.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables broad specificity oxidative DNA demethylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA demethylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: oxidoreductase, 2OG-Fe(II) oxygenase family protein

NP_565530.1

oxidoreductase, 2OG-Fe(II) oxygenase family protein; FUNCTIONS IN: oxidoreductase activity; INVOLVED IN: metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT2G22270.1); Has 1561 Blast hits to 1561 proteins in 515 species: Archae - 0; Bacteria - 839; Metazoa - 118; Fungi - 181; Plants - 86; Viruses - 14; Other Eukaryotes - 323 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

9460918..9463561

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001335786.1 → NP_001325000.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SIE0

UniProtKB/TrEMBL

A0A654EV15
NM_001335788.1 → NP_001324999.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SIE0

UniProtKB/TrEMBL

A0A654EV15
NM_001335787.1 → NP_001324995.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B1U3
NM_127792.4 → NP_565530.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565530.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SIE0

UniProtKB/TrEMBL

A0A654EV15

Conserved Domains (2) summary

pfam13266
Location:7 → 63

DUF4057; Protein of unknown function (DUF4057)

cl21496
Location:106 → 311

2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
NM_001335789.1 → NP_001324998.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SIE0

UniProtKB/TrEMBL

A0A654EV15
NM_001335790.1 → NP_001324997.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VU09, A0A1P8B1V2, A0A5S9X059
NM_001335791.1 → NP_001324996.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B1U3
NM_001335792.1 → NP_001324994.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B1U3
NM_001335793.1 → NP_001324993.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B1T8, A0A654EV15