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Cbl E3 ubiquitin-protein ligase CBL [ Ixodes scapularis (black-legged tick) ]

Gene ID: 8032556, updated on 23-May-2024

Summary

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Gene symbol
Cbl
Gene description
E3 ubiquitin-protein ligase CBL
See related
VectorBase:ISCP_027382; EnsemblRapid:LOC8032556
Gene type
protein coding
RefSeq status
MODEL
Organism
Ixodes scapularis
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari; Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes
Orthologs
fruit fly all
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Genomic context

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See Cbl in Genome Data Viewer
Location:
chromosome: Un
Exon count:
12
Annotation release Status Assembly Chr Location
103 current ASM1692078v2 (GCF_016920785.2) Unplaced Scaffold NW_024609835.1 (98885524..98949095, complement)
102 previous assembly Ixodes_scapularus_ComboLowHiFi (GCF_016920785.1) Unplaced Scaffold NW_024388240.1 (803129..865741)

NW_024609835.1Genomic Context describing neighboring genes Neighboring gene retinoblastoma binding protein 5 Neighboring gene uncharacterized LOC115313167 Neighboring gene TBC1 domain family member 23 Neighboring gene uncharacterized LOC8032555 Neighboring gene uncharacterized LOC115318884

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL-B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Ixodes scapularis Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1692078v2

Genomic

  1. NW_024609835.1 Reference ASM1692078v2

    Range
    98885524..98949095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002410233.5 → XP_002410277.2  E3 ubiquitin-protein ligase CBL-B

    Related
    XP_002410277.2, XM_002410233.5
    Conserved Domains (5) summary
    cd09920
    Location:242 → 338
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14318
    Location:731 → 769
    UBA_Cbl_like; UBA domain found in casitas B-lineage lymphoma (Cbl) proteins
    cd16709
    Location:348 → 413
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:40 → 158
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:165 → 248
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
Nucleotide Protein
Heading Accession and Version

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