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p4htmb prolyl 4-hydroxylase, transmembrane b [ Danio rerio (zebrafish) ]

Gene ID: 799930, updated on 18-Sep-2024

Summary

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Official Symbol
p4htmbprovided by ZNC
Official Full Name
prolyl 4-hydroxylase, transmembrane bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110131-7
See related
Ensembl:ENSDARG00000075209 AllianceGenome:ZFIN:ZDB-GENE-110131-7
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
p4htm; si:ch211-157b11.10
Summary
Predicted to enable procollagen-proline 4-dioxygenase activity. Acts upstream of or within glomerular basement membrane development and pronephric glomerulus development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Orthologous to human P4HTM (prolyl 4-hydroxylase, transmembrane). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See p4htmb in Genome Data Viewer
Location:
chromosome: 6
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (40734052..40744701, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (40736564..40747181, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene interactor of HORMAD1 1 Neighboring gene kelch repeat and BTB (POZ) domain containing 12 Neighboring gene solute carrier family 26 member 6, like 1 Neighboring gene myosin, heavy chain b Neighboring gene actin related protein 2/3 complex, subunit 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Anti-Hypoxic Molecular Mechanisms of Rhodiola crenulata Extract in Zebrafish as Revealed by Metabonomics. Ma Y, et al. Front Pharmacol, 2019. PMID 31780949, Free PMC Article
  2. Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function. Hyvärinen J, et al. J Biol Chem, 2010 Dec 31. PMID 20952382, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-proline 4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glomerular basement membrane development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pronephric glomerulus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of erythrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane prolyl 4-hydroxylase
Names
P4H-TM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    40734052..40744701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001340198.6 → XP_001340234.2  transmembrane prolyl 4-hydroxylase

    UniProtKB/TrEMBL
    A0A8M1PZD9, X1WG80
    Related
    ENSDARP00000129235.1, ENSDART00000154916.2
    Conserved Domains (3) summary
    smart00702
    Location:285 → 471
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam13499
    Location:204 → 262
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:204 → 262
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein Strain
Heading Accession and Version

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