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slc8a1b solute carrier family 8 member 1b [ Danio rerio (zebrafish) ]

Gene ID: 797199, updated on 12-Sep-2024

Summary

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Official Symbol
slc8a1bprovided by ZNC
Official Full Name
solute carrier family 8 member 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060110-3
See related
Ensembl:ENSDARG00000043406 AllianceGenome:ZFIN:ZDB-GENE-060110-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ncx1n
Summary
Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in calcium ion import across plasma membrane and sodium ion transmembrane transport. Predicted to act upstream of or within cell communication; metal ion transport; and transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in axon; postsynapse; and sarcolemma. Predicted to be integral component of plasma membrane. Is expressed in several structures, including blood; eye; liver; neural tube; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 17
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (22379530..22505224)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (22328987..22482112)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S5 Neighboring gene uncharacterized LOC137488095 Neighboring gene uncharacterized LOC137488096 Neighboring gene EDAR-associated death domain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of ambient cadmium with calcium on mRNA expressions of calcium uptake related transporters in zebrafish (Danio rerio) larvae. Liu CT, et al. Fish Physiol Biochem, 2012 Aug. PMID 22179751
  2. Effects of stanniocalcin 1 on calcium uptake in zebrafish (Danio rerio) embryo. Tseng DY, et al. Am J Physiol Regul Integr Comp Physiol, 2009 Mar. PMID 19073903
  3. Hydrogen sulfide promotes calcium uptake in larval zebrafish. Kwong RW, et al. Am J Physiol Cell Physiol, 2015 Jul 1. PMID 25948733, Free PMC Article
  4. Inhibition of calcium uptake during hypoxia in developing zebrafish is mediated by hypoxia-inducible factor. Kwong RW, et al. J Exp Biol, 2016 Dec 15. PMID 27802147
  5. Involvement of the calcium-sensing receptor in calcium homeostasis in larval zebrafish exposed to low environmental calcium. Kwong RW, et al. Am J Physiol Regul Integr Comp Physiol, 2014 Feb 15. PMID 24381181, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium:sodium antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium:sodium antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell communication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within enteric nervous system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium/calcium exchanger 1b
Names
ncx1b
sodium calcium exchanger 1n
solute carrier family 8 (sodium/calcium exchanger), member 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039144.1 → NP_001034233.1  sodium/calcium exchanger 1b precursor

    See identical proteins and their annotated locations for NP_001034233.1

    Status: PROVISIONAL

    Source sequence(s)
    AY934776
    UniProtKB/TrEMBL
    A0A8M1N8A3, E9QGW4, Q32SG7
    Related
    ENSDARP00000109925.3, ENSDART00000128875.4
    Conserved Domains (5) summary
    smart00237
    Location:542 → 632
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:36 → 944
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:771 → 935
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:411 → 501
    Calx-beta; Calx-beta domain
    pfam16494
    Location:258 → 389
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    22379530..22505224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158697.5 → XP_005158754.1  sodium/calcium exchanger 1b isoform X2

    See identical proteins and their annotated locations for XP_005158754.1

    UniProtKB/TrEMBL
    A0A8M2B5K7, B2CZC2
    Related
    ENSDARP00000126373.1, ENSDART00000151929.3
    Conserved Domains (5) summary
    smart00237
    Location:542 → 632
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:36 → 942
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:769 → 933
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:411 → 501
    Calx-beta; Calx-beta domain
    pfam16494
    Location:258 → 389
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

  2. XM_005158696.5 → XP_005158753.1  sodium/calcium exchanger 1b isoform X1

    See identical proteins and their annotated locations for XP_005158753.1

    UniProtKB/TrEMBL
    A0A8M1N8A3, E9QGW4, Q32SG7
    Conserved Domains (5) summary
    smart00237
    Location:542 → 632
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:36 → 944
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:771 → 935
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:411 → 501
    Calx-beta; Calx-beta domain
    pfam16494
    Location:258 → 389
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

  3. XM_009293025.4 → XP_009291300.1  sodium/calcium exchanger 1b isoform X1

    See identical proteins and their annotated locations for XP_009291300.1

    UniProtKB/TrEMBL
    A0A8M1N8A3, E9QGW4, Q32SG7
    Conserved Domains (5) summary
    smart00237
    Location:542 → 632
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:36 → 944
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:771 → 935
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:411 → 501
    Calx-beta; Calx-beta domain
    pfam16494
    Location:258 → 389
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

  4. XM_021467243.2 → XP_021322918.1  sodium/calcium exchanger 1b isoform X3

    UniProtKB/TrEMBL
    A0A8M9P932
    Conserved Domains (1) summary
    cl02522
    Location:35 → 310
    Calx-beta; Calx-beta domain

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395328.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    91139..218920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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