aurkb aurora kinase B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aurkbprovided by ZNC
Official Full Name: aurora kinase Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020419-40
See related: Ensembl:ENSDARG00000037640 AllianceGenome:ZFIN:ZDB-GENE-020419-40
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cei; aurB; stka; fa09g06; fd02h12; CHUNP6896; wu:fa09g06; wu:fd02h12
Summary: Predicted to enable histone serine kinase activity. Acts upstream of or within chromosome segregation; cytoskeleton-dependent cytokinesis; and microtubule cytoskeleton organization. Predicted to be located in midbody and nucleus. Predicted to be part of chromosome passenger complex. Predicted to be active in spindle microtubule; spindle midzone; and spindle pole centrosome. Is expressed in several structures, including blastomere; midbrain hindbrain boundary; nervous system; and proliferative region. Human ortholog(s) of this gene implicated in spermatogenic failure 5. Orthologous to human AURKB (aurora kinase B) and AURKC (aurora kinase C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (241461..246396, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (34043..38978, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest a role of AurkB in regulating neuronal development and axonal outgrowth.
Title: Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish.
Aurora B kinase is essential for furrow induction and maturation in the zebrafish embryo.
Title: The maternal-effect gene cellular island encodes aurora B kinase and is essential for furrow formation in the early zebrafish embryo.

Submit: New GeneRIF Correction

General gene information

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Markers

fa09g06.s1 (e-PCR)
- UniSTS:202264

fd02h12.x1 (e-PCR)
- UniSTS:194874

fe01g09.x1 (e-PCR)
- UniSTS:195919

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in abscission	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cleavage furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cleavage furrow formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic sister chromatid biorientation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle midzone assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of B cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitotic sister chromatid segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-translational protein modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in repair of mitotic kinetochore microtubule attachment defect	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
is_active_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aurora kinase B

Names: aurora-B; cellular island; serine/threonine kinase a; serine/threonine-protein kinase 12; serine/threonine-protein kinase aurora-B

NP_997731.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212566.2 → NP_997731.2 aurora kinase B

Status: VALIDATED

Source sequence(s)

FP243378

UniProtKB/Swiss-Prot

Q6NW76, Q8JGS8

UniProtKB/TrEMBL

A0A8M1PKP6, F1RDC1

Related

ENSDARP00000054822.5, ENSDART00000054823.7

Conserved Domains (2) summary

smart00220
Location:53 → 303

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14117
Location:46 → 315

STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins