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Adamtsl1 ADAMTS-like 1 [ Mus musculus (house mouse) ]

Gene ID: 77739, updated on 17-Aug-2024

Summary

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Official Symbol
Adamtsl1provided by MGI
Official Full Name
ADAMTS-like 1provided by MGI
Primary source
MGI:MGI:1924989
See related
Ensembl:ENSMUSG00000066113 AllianceGenome:MGI:1924989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADAMTSL-1; 5930437A14Rik; 6720426B09Rik
Summary
Predicted to be involved in extracellular matrix organization. Located in collagen-containing extracellular matrix. Orthologous to human ADAMTSL1 (ADAMTS like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 6.7), limb E14.5 (RPKM 4.3) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C4; 4 40.32 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (85432242..86346627)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (85513852..86428390)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10676 Neighboring gene STARR-seq mESC enhancer starr_10677 Neighboring gene STARR-seq mESC enhancer starr_10679 Neighboring gene RAN, member RAS oncogene family pseudogene Neighboring gene SH3-domain GRB2-like 2 Neighboring gene phosphoglycerate mutase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10684 Neighboring gene STARR-seq mESC enhancer starr_10685 Neighboring gene STARR-seq mESC enhancer starr_10686 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_10687 Neighboring gene predicted gene, 25811 Neighboring gene STARR-seq mESC enhancer starr_10689 Neighboring gene STARR-seq mESC enhancer starr_10690 Neighboring gene STARR-seq mESC enhancer starr_10691 Neighboring gene STARR-seq mESC enhancer starr_10692 Neighboring gene STARR-seq mESC enhancer starr_10693 Neighboring gene predicted gene, 33730 Neighboring gene STARR-positive B cell enhancer mm9_chr4:86183948-86184249 Neighboring gene stabilizer of axonemal microtubules 1 Neighboring gene predicted gene, 26017 Neighboring gene stabilizer of axonemal microtubules 1, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix. Hirohata S, et al. J Biol Chem, 2002 Apr 5. PMID 11805097
  2. ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases. Hall NG, et al. Matrix Biol, 2003 Nov. PMID 14667842
  3. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
  4. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Naba A, et al. Mol Cell Proteomics, 2012 Apr. PMID 22159717, Free PMC Article
  5. Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Naba A, et al. Sci Rep, 2017 Jan 10. PMID 28071719, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ADAMTS-like protein 1
Names
punctin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368621.1 → NP_001355550.1  ADAMTS-like protein 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL772130, AL807242, AL824705
    UniProtKB/Swiss-Prot
    A2AM52, Q8BLI0
    Related
    ENSMUSP00000119278.2, ENSMUST00000141889.8
    Conserved Domains (7) summary
    smart00408
    Location:891 → 949
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:36 → 82
    TSP1; Thrombospondin type 1 repeats
    PTZ00441
    Location:434 → 506
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    cd00096
    Location:1304 → 1375
    Ig; Immunoglobulin domain
    cl15278
    Location:529 → 583
    TSP_1; Thrombospondin type 1 domain
    pfam07679
    Location:1414 → 1494
    I-set; Immunoglobulin I-set domain
    pfam08686
    Location:1738 → 1767
    PLAC; PLAC (protease and lacunin) domain

  2. NM_029967.3 → NP_084243.3  ADAMTS-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AK020115, AK045085, AK132420, AL807242, AL824705, CJ051149, CV555842
    Consensus CDS
    CCDS51217.1
    UniProtKB/Swiss-Prot
    A2AM52, Q8BLI0
    UniProtKB/TrEMBL
    E9PWW5
    Related
    ENSMUSP00000102796.3, ENSMUST00000107178.9
    Conserved Domains (6) summary
    smart00408
    Location:1284 → 1351
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:36 → 82
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:1269 → 1361
    IG_like; Immunoglobulin like
    pfam08686
    Location:1721 → 1750
    PLAC; PLAC (protease and lacunin) domain
    cl11960
    Location:1180 → 1240
    Ig; Immunoglobulin domain
    cl15278
    Location:514 → 566
    TSP_1; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    85432242..86346627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538375.3 → XP_006538438.1  ADAMTS-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AM52, Q8BLI0
    Conserved Domains (6) summary
    smart00408
    Location:1647 → 1713
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:265 → 311
    TSP1; Thrombospondin type 1 repeats
    PTZ00441
    Location:663 → 735
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    cd00096
    Location:1533 → 1604
    Ig; Immunoglobulin domain
    pfam08686
    Location:1967 → 1996
    PLAC; PLAC (protease and lacunin) domain
    cl15278
    Location:760 → 812
    TSP_1; Thrombospondin type 1 domain

  2. XM_006538376.3 → XP_006538439.1  ADAMTS-like protein 1 isoform X2

    UniProtKB/Swiss-Prot
    A2AM52, Q8BLI0
    Conserved Domains (5) summary
    smart00408
    Location:1630 → 1696
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:265 → 311
    TSP1; Thrombospondin type 1 repeats
    PTZ00441
    Location:646 → 718
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    cd00096
    Location:1516 → 1587
    Ig; Immunoglobulin domain
    cl15278
    Location:743 → 795
    TSP_1; Thrombospondin type 1 domain

  3. XM_036164549.1 → XP_036020442.1  ADAMTS-like protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AM52, Q8BLI0
    Conserved Domains (7) summary
    smart00408
    Location:1078 → 1136
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:223 → 269
    TSP1; Thrombospondin type 1 repeats
    pfam08686
    Location:1925 → 1954
    PLAC; PLAC (protease and lacunin) domain
    pfam13927
    Location:1472 → 1552
    Ig_3; Immunoglobulin domain
    pfam19030
    Location:857 → 915
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cd00096
    Location:1491 → 1495
    Ig; Ig strand B [structural motif]
    cl11960
    Location:1384 → 1444
    Ig; Immunoglobulin domain

  4. XM_006538378.5 → XP_006538441.1  ADAMTS-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006538441.1

    UniProtKB/Swiss-Prot
    A2AM52, Q8BLI0
    Conserved Domains (5) summary
    smart00408
    Location:1418 → 1484
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:36 → 82
    TSP1; Thrombospondin type 1 repeats
    PTZ00441
    Location:434 → 506
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    cd00096
    Location:1304 → 1375
    Ig; Immunoglobulin domain
    cl15278
    Location:531 → 583
    TSP_1; Thrombospondin type 1 domain

  5. XM_036164550.1 → XP_036020443.1  ADAMTS-like protein 1 isoform X5

    UniProtKB/Swiss-Prot
    A2AM52, Q8BLI0
    Conserved Domains (6) summary
    smart00408
    Location:874 → 932
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:36 → 82
    TSP1; Thrombospondin type 1 repeats
    pfam13927
    Location:1268 → 1348
    Ig_3; Immunoglobulin domain
    pfam19030
    Location:653 → 711
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cd00096
    Location:1287 → 1291
    Ig; Ig strand B [structural motif]
    cl11960
    Location:1180 → 1240
    Ig; Immunoglobulin domain

  6. XM_030253919.2 → XP_030109779.1  ADAMTS-like protein 1 isoform X6

    Conserved Domains (4) summary
    smart00408
    Location:950 → 1016
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:322 → 381
    TSP1; Thrombospondin type 1 repeats
    cd00096
    Location:836 → 907
    Ig; Immunoglobulin domain
    cl15278
    Location:63 → 115
    TSP_1; Thrombospondin type 1 domain

  7. XM_006538380.3 → XP_006538443.1  ADAMTS-like protein 1 isoform X6

    See identical proteins and their annotated locations for XP_006538443.1

    Conserved Domains (4) summary
    smart00408
    Location:950 → 1016
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:322 → 381
    TSP1; Thrombospondin type 1 repeats
    cd00096
    Location:836 → 907
    Ig; Immunoglobulin domain
    cl15278
    Location:63 → 115
    TSP_1; Thrombospondin type 1 domain

  8. XM_006538379.4 → XP_006538442.1  ADAMTS-like protein 1 isoform X6

    See identical proteins and their annotated locations for XP_006538442.1

    Conserved Domains (4) summary
    smart00408
    Location:950 → 1016
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:322 → 381
    TSP1; Thrombospondin type 1 repeats
    cd00096
    Location:836 → 907
    Ig; Immunoglobulin domain
    cl15278
    Location:63 → 115
    TSP_1; Thrombospondin type 1 domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172542.1: Suppressed sequence

    Description
    NM_172542.1: This RefSeq was permanently suppressed because the CDS was partial.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BLI0.2 GenPept UniProtKB/Swiss-Prot:Q8BLI0

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