DLX6 distal-less homeobox 6 [Gallus gallus (chicken)] - Gene

Summary

Symbol: DLX6provided by CGNC
Full Name: distal-less homeobox 6provided by CGNC
Primary source: CGNC:16126
See related: Ensembl:ENSGALG00010002948
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (24346981..24350502)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (24377186..24380708)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We find Dlx5 and Dlx6 to be quantitatively indistinguishable on a variety of natural cis-regulatory sequences in a heterologous cellular context but observed quantitatively different transcriptional outputs in cells that normally express these genes, suggesting differential interactions with co-evolved co-activators.
Title: Measuring inputs to a common function: The case of Dlx5 and Dlx6.
Inner ear expression patterns of Dlx3, Dlx5, and Dlx6 were examined during the first 7 days of chicken embryonic development.
Title: Dlx gene expression during chick inner ear development.
ectethmoid formation depends upon Dlx5 and Dlx6 expression in a restricted ectodermal territory of the anterior neural folds
Title: Dlx5 and Dlx6 expression in the anterior neural fold is essential for patterning the dorsal nasal capsule.
Dlx5 and 6 genes may be involved in specification of the elbow joint and/or in providing positional information that specifies the site at which the elbow joint will form
Title: Expression of Dlx5 and Dlx6 during specification of the elbow joint.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in embryo development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: homeobox protein DLX-6

Names: homeodomain transcription factor DLX6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080890.2 → NP_001074359.2 homeobox protein DLX-6

Status: VALIDATED

Source sequence(s)

JAENSK010000036

UniProtKB/TrEMBL

F1NCY8, Q6DV99

Related

ENSGALP00010004181.1, ENSGALT00010006861.1

Conserved Domains (1) summary

pfam00046
Location:144 → 198

Homeobox; Homeobox domain